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National Repository of Grey Literature

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	Nutritional factors in the etiopathogenesis of colorectal cancer Nekvindová, Jana ; Hronek, Miloslav (advisor) ; Vopršalová, Marie (referee) Detailed record
	Monitoring of the expression of mRNA for CD 105 in patients with the chronic lymphocytic leukemia Černý, Miroslav ; Fátorová, Ilona (advisor) ; Nekvindová, Jana (referee) CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Miroslav Černý Supervisor: Mgr. Ilona Fátorová Consultant: Mgr. Filip Vrbacký Title of diploma thesis: Monitoring of the expression of mRNA for CD105 in patients with the chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is heterogenous disease with very variable clinical course. Early determination of prognosis of this disorder can be helpful for finding and initiation of adequate individual therapy. Angiogenesis has prognostic potential and plays probably important role in pathogenesis of CLL. Endoglin (CD105) and angiopoietin 2 (Ang-2) also belong to angiogenic molecules. Data about expression of these molecules are still insufficient. Therefore, we quantitated CD105 and Ang-2 mRNA in B cells of 49 untreated CLL patients by using the method of real-time quantitative PCR. Subsequently, we compared the expression of these angiogenic molecules to traditional as well as modern biological prognostic factors(Rai clinical stage, disease course, IgVH mutation status, expression of ZAP70 and CD38). We found statistical significant association between expression of CD105 and all traditional or modern prognostic factors (Rai0 versus I - IV: p = 0,004; disease course:... Detailed record
	Nutritional factors in the etiopathogenesis of colorectal cancer Nekvindová, Jana ; Hronek, Miloslav (advisor) ; Vopršalová, Marie (referee) Detailed record

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