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Problems of biocompatibility in renal replacement therapy
Polanská, Kamila ; Opatrná, Sylvie (advisor) ; Tesař, Vladimír (referee) ; Mydlík, Miroslav (referee)
.Summary 7.1. The effect of heparin rinse on selected biocompatibility parameters in continuous extracorporeal renal replacement therapy methods In her study assessing the effect of heparin on biocompatibility parameters in continuous renal replacement therapy methods, the author has made the following conclusions: 1) Patients scheduled for CVVHDF show comprehensive hemostasis impairment involving thrombocyte activation, coagulation, and fibrinolysis. 2) These patients show, already prior to CVVHDF initiation, signs of activation of complement with high C5a levels and, also, high leukocyte count compared with a control group of healthy individuals. 3) Preparation of the extracorporeal circuit before CVVHDF using various techniques of rinse (heparin-free saline, saline with 2,000 IU heparin/L and one-hour saline rinse using 10,000 IU heparin/L with recirculation) has no effect on the behavior of thrombogenicity parameters, complement activation and leukocyte count during CVVHDF and will not reduce the consumption of anticoagulants administered. Hence, it can be concluded that heparin rinse of the extracorporeal circuit prior to CVVHDF initiation will confer no benefit in terms of reduced thrombogenicity, need for anticoagulants, and elimination of the adverse effect of the artificial surface on the other...
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Problems of biocompatibility in renal replacement therapy
Polanská, Kamila ; Opatrná, Sylvie (advisor) ; Tesař, Vladimír (referee) ; Mydlík, Miroslav (referee)
.Summary 7.1. The effect of heparin rinse on selected biocompatibility parameters in continuous extracorporeal renal replacement therapy methods In her study assessing the effect of heparin on biocompatibility parameters in continuous renal replacement therapy methods, the author has made the following conclusions: 1) Patients scheduled for CVVHDF show comprehensive hemostasis impairment involving thrombocyte activation, coagulation, and fibrinolysis. 2) These patients show, already prior to CVVHDF initiation, signs of activation of complement with high C5a levels and, also, high leukocyte count compared with a control group of healthy individuals. 3) Preparation of the extracorporeal circuit before CVVHDF using various techniques of rinse (heparin-free saline, saline with 2,000 IU heparin/L and one-hour saline rinse using 10,000 IU heparin/L with recirculation) has no effect on the behavior of thrombogenicity parameters, complement activation and leukocyte count during CVVHDF and will not reduce the consumption of anticoagulants administered. Hence, it can be concluded that heparin rinse of the extracorporeal circuit prior to CVVHDF initiation will confer no benefit in terms of reduced thrombogenicity, need for anticoagulants, and elimination of the adverse effect of the artificial surface on the other...
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