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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The role of Prdm9 in the house mouse hybrid sterility model
 Mukaj, Amisa ; Parvanov, Emil (advisor) ; Děd, Lukáš (referee) ; Reifová, Radka (referee)
(English) Hybrid sterility is a phenomenon representing reproductive isolation between closely related species and thus assuring the process of speciation. Hybrid sterility is a complex polygenic trait and the most significant advance in its study is achieved in Drosophila melanogaster. Nearly half century ago Forejt and Ivanyi mapped the first hybrid sterility genetic locus in vertebrates (Hybrid sterility 1, Hst1) in crosses of wild mice with laboratory inbred strains where the male offspring is sterile. Further mapping of the locus led to discovery of a gene called PR domain zinc finger protein 9 (Prdm9), a histone methyltransferase, whose deficiency causes meiotic arrest and sterility in mice. Furthermore, it was found that Prdm9 defines the hotspot placement in meiotic recombination by posting trimethylation marks on lysine residues 4 and 36 of histone 3 hence explaining the observed defects in its absence during meiosis. Nonetheless, its exact role in molecular mechanism of hybrid sterility is yet unclear. Prdm9 expression is present during the stage of formation of meiotic DNA double-strand breaks and is a hint about the time of hybrid sterility initiation. Phenotypically in the case of male mouse hybrid sterility is observed incomplete chromosome synapsis, meiotic arrest at mid-to-late...
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