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National Repository of Grey Literature

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	Polymerní konjugát doxorubicinu na bázi HPMA, působící ve shodě s protinádorovou imunitou nositele Šírová, Milada ; Rossmann, Pavel ; Mrkvan, Tomáš ; Strohalm, Jiří ; Šubr, Vladimír ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Polymeric conjugate Dox-HPMA-HuIg directly targets the tumour due to the EPR effect, it is not detrimental towards the immune system of the host, and acts in concert with the anti-tumour immune responses Detailed record
	Imunostimulační a imunoprotektivní vlastnosti makromolekulárních protinádorových léčiv Říhová, Blanka ; Strohalm, Jiří ; Šírová, Milada ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šubr, Vladimír ; Plocová, Daniela ; Kovář, Marek ; Ulbrich, Karel Polymeric conjugates of doxorubicin, non-targeted or antibody targeted cure mice from experimental EL4 T cell lymphoma and induce specific, systemic long-lasting anti/tumor resistance Detailed record
	Indukce efektivní protinádorové imunity při léčbě směrovaným konjugátem na bázi poly(HPMA) obsahujícím doxorubicin Kovář, Marek ; Tomala, Jakub ; Mrkvan, Tomáš ; Etrych, Tomáš ; Strohalm, Jiří ; Ulbrich, Karel ; Říhová, Blanka Thus, treatment with B1 mAb-targeted conjugates is able to completely cured BCL 1 bearing mice and most importantly, break immunoescaping mechanisms of BCL1 cells Detailed record
	Směrovaná polymerní protinádorová léčiva na bázi HPMA v terapii HNSCC Bouček, Jan ; Betka, J. ; Strohalm, Jiří ; Plocová, Daniela ; Šubr, Vladimír ; Mrkvan, Tomáš ; Ulbrich, Karel ; Říhová, Blanka Targeted conjugates are promising novel drugs and especially anti-EGFR targeted conjugates seem to be a perspective modality in treating HNSCC or other cancers over-expressing EGFR receptor Detailed record
	Vliv N-(2-hydroxypropyl)methacrylamidového kopolymeru obsahujícího doxorubicin na mitogenem aktivované protein kinázové signalizační dráhy Kovář, Lubomír ; Strohalm, Jiří ; Chytil, Petr ; Plocová, Daniela ; Mrkvan, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We demonstrated that the mitogen-activated protein kinases (MAPKs) play a crucial role in cancer cell death and survival, however their role seems to be indirect. We confirmed the previously published results showing that different intracellular processes are underway in cancer cells treated with Dox.HCl compared to those incubated with HPMA conjugates Detailed record
	In vitro účinnost polymerních konjugátů směrovaných mAb anti-EGFR nebo lidským polyklonálním IgG Bouček, Jan ; Betka, J. ; Strohalm, Jiří ; Plocová, Daniela ; Šubr, Vladimír ; Mrkvan, Tomáš ; Ulbrich, Karel ; Říhová, Blanka Targered prodrugs are promising novel agents and especially anti-EGFR targered conjugates seem to be a perspective modality in treating HNSCC Detailed record
	Směrovaná polymerní léčiva pro terapii nádorových onemocnění Kovář, Marek ; Mrkvan, Tomáš ; Šírová, Milada ; Strohalm, Jiří ; Šubr, Vladimír ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We have presented data on development of polymer-bound cytostatic drugs and their therapeutic efficacy in selected tumor models Detailed record
	Anti-cancer drugs with immunoprotective/immunomodulatory effect Říhová, Blanka ; Etrych, Tomáš ; Kovář, Marek ; Chytil, Petr ; Hovorka, Ondřej ; Plocová, Daniela ; Mrkvan, Tomáš ; Strohalm, Jiří ; Šírová, Milada ; Šubr, Vladimír ; Kubáčková, K. ; Ulbrich, Karel Cytotoxic drugs based on HPMA polymer show direct cytotoxic and cytostatic effect together with an ability to mobilize the immune system. Two types of linkage of the drug to the polymer are discussed, as well as linkage-related differences in tumour cell accumulation and fate of the cells Detailed record
	Kopolymery na bázi HPMA s pH-řízeným uvolňováním doxorubicinu v protinádorové terapii umožňují imunitnímu systému rozpoznat nádor Mrkvan, Tomáš ; Šírová, Milada ; Etrych, Tomáš ; Chytil, Petr ; Strohalm, Jiří ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Therapy with HPMA-based conjugates triggers effective anti-tumour immunity early during the course of the treatment. Activated immune system, in addition to direct cytotoxic effect the drug, is responsible for the eradication of established tumour Detailed record
	Protinádorová účinnost konjugátu na bázi N-(2-hydroxypropyl)metakrylamidu, obsahujícího doxorubicin a normální lidský imunoglobulin Šírová, Milada ; Strohalm, Jiří ; Rossmann, Pavel ; Mrkvan, Tomáš ; Šubr, Vladimír ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Polymeric conjugate based on HPMA containing cytotoxic drug (doxorubicin) and human “non-specific” immunoglobulin has a significant anti-tumour effect and does not impair immune functions of the host. C57BL/6 mice with EL-4 lymphoma, when completely cured with the conjugate, were protected against the same tumour due to a specific anti-tumour immune reaction Detailed record

National Repository of Grey Literature : 15 records found   1 - 10  jump to record:

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