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Formulation of nanoparticles with terbinafine
Mrázková, Nikola ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Nikola Mrázková Supervisor of Diploma thesis: Doc. RNDr. Milan Dittrich CSc. Title of Diploma thesis: Formulation of nanoparticles with terbinafine In the theoretical part of this diploma thesis is presented review concerning basic applications of nanotechnology in health service, characteristic of nanoparticles, their dividing and use in pharmacotherapy, especially in targeted drug transport. The focus of the thesis presented here is in experimental part. Particles of submicrom size were fabricated by the using of emusion solvent distribution method in the emulsion of o/w type. Star-like terpolymer of DL- lactic acid and glycolic acid branched on tripentaerytritole as core was used as potential drug carrier. The aim was to prepare the smallest particles as possible. The size and the size distribution were measured by the PCS method by the using of the device Zeta Sizer ZS. The impact of two from the chemical point of view different emulsifiers and two emulsion concentrations on the granulometric parameters of the prepared particles was evaluated. The stability of parameters during storage at lowered temperature and in the frozen state during the one day period after preparation was...
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Relationship of recent systematics of frogs (Anura) and research efforts
MRÁZKOVÁ, Nikola
Over the last few decades there has been a confusion in the classification system of organisms with the development of molecular and genetic methods. Life is currently perceived from a different perspective than in the past due to different methods, and old, standard systems have significantly changed as a result of such alteration. As a consequence, it is harder and harder to distinguish which taxonomic changes are caused by objectively better recognition of biodiversity and which seem to be only subjective opinions of particular taxonomists. Results show a significant growth in the number of genuses in observed families of frogs (Anura) in the aforementioned period (2000-2017) while the research efforts of taxonoms were proved to be the most relevant factors causing such increase in diversity with respect to genuses.
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Formulation of nanoparticles with terbinafine
Mrázková, Nikola ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Nikola Mrázková Supervisor of Diploma thesis: Doc. RNDr. Milan Dittrich CSc. Title of Diploma thesis: Formulation of nanoparticles with terbinafine In the theoretical part of this diploma thesis is presented review concerning basic applications of nanotechnology in health service, characteristic of nanoparticles, their dividing and use in pharmacotherapy, especially in targeted drug transport. The focus of the thesis presented here is in experimental part. Particles of submicrom size were fabricated by the using of emusion solvent distribution method in the emulsion of o/w type. Star-like terpolymer of DL- lactic acid and glycolic acid branched on tripentaerytritole as core was used as potential drug carrier. The aim was to prepare the smallest particles as possible. The size and the size distribution were measured by the PCS method by the using of the device Zeta Sizer ZS. The impact of two from the chemical point of view different emulsifiers and two emulsion concentrations on the granulometric parameters of the prepared particles was evaluated. The stability of parameters during storage at lowered temperature and in the frozen state during the one day period after preparation was...
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