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Interaction of the selected natural substances with conventional drugs
Mottlová, Eliška ; Tůmová, Lenka (advisor) ; Mladěnka, Přemysl (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacognosy Supervisor: Assoc. Prof. PharmDr. Lenka Tůmová, Ph.D. Student: Eliška Mottlová Title of Thesis: Interactions of the selected natural substances with conventional medicine Keywords: medicinal plant, anthraquinones, saponins, tannins, alkaloids, interactions The aim of this diploma thesis is to give an overview of interactions which could occur during simultaneous use of conventional drugs and medicinal plants containing anthraquinones, saponins, tannins or isolated plant alkaloids. Information about herb-drug interactions were obtain and cited mostly from articles of online databases (Web of Science, Science Direct, PubMed, Google scholar) published in period 2000 - 2019. Interactions of 12 medicinal plants and 12 isolated plant alkaloids are mentioned in the thesis. The most significant interactions usually appear in combination of herbal products and drugs with narrow therapeutic index such as warfarin, digoxin, cyclosporin or theophylline. St John's wort affects the metabolism of drugs through induction of CYP450 enzymes (CYP3A4, CYP2C9, CYP2C19) or P- glycoprotein and also St John's wort can increase the risk of serotonin syndrome in combination with SNRI, SSRI or triptanes. Medicinal plants containing...
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