|
|
Antiplatelet effects of 5,7-dihydroxy-4-methylcoumarins
Morkusová, Michaela ; Mladěnka, Přemysl (advisor) ; Fikrová, Petra (referee)
1 Abstrakt v angličtině Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Michela Morkusová, MSc. Supervisor: Assoc. Prof. Přemysl Mladěnka, Pharm.D., Ph.D. Title of diploma thesis: Antiplatelet effects of 5,7-dihydroxy-4-methylcoumarins Haemostasis is a complex physiological process which leads to a spontaneous stop of the bleeding from a damaged blood vessel. However, the aggregation of blood platelets followed by thrombus formation in coronary arteries damaged by atherosclerosis is the key risk factor for development of acute myocardial infarction. The antiplatelet therapy is a basic intervention in prevention and treatment of cardiovascular diseases. The current treatment procedures are able to decrease the occurrence of cardiovascular incidents, but are linked to a higher risk of bleeding and in some resistant cases are not effective at all. Therefore it is important to search for new antiplatelet medications that will have more favourable properties and that will ensure treatment free of many limitations. This study analysed the mechanism of action of antiplatelet effect in three 5,7- dihydroxy-4-methylcoumarin compounds that were proved to decrease platelet aggregation after application of arachidonic acid in the similar concentration...
|
|
|
Chelation ability of experimentally used iron chelators
Morkusová, Michaela ; Mladěnka, Přemysl (advisor) ; Pávek, Petr (referee)
v angličtině Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Michela Morkusová Supervisor: Přemysl Mladěnka, Pharm.D., Ph.D. Title of diploma thesis: Chelation ability of experimentally used iron chelators Iron is a vital element, playing many important functions in the body. Its presence in too low or too high quantities is harmful. The body has no excretion route for iron, and in certain circumstances, excess iron can accumulate in body tissues. Iron is present in the body in excess particularly in individuals undergoing frequent blood transfusions or having genetically based diseases associated with iron overload (hemochromatosis). Iron excess is medically treated by administration of iron chelators. Such substances can find wider therapeutic use as well, e.g. in individuals with acute myocardial infarction or with tumours. This Thesis was aimed at determining the stoichiometric ratio in the complexes of two experimental chelators, salicylaldehyde isonicotinoyl hydrazone (SIH) and ethylenediaminetetraacetic acid (EDTA), with iron(II) and iron(III) ions at four different pathophysiologically significant pH levels (4.5, 5.5, 6.8 and 7.5). Spectrophotometry was used as the analytical method. In the processing stage, various new...
|
guest ::
