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Coordinatively unsaturated complexes of macrocyclic amides
Mojžíšová, Adéla ; Kotek, Jan (advisor) ; Vojtíšek, Pavel (referee)
Growing number of citizens in developed countries suffers from neurodegenerative diseases. According to World Health Organization (WHO) dementias affect 55,2 million people and their incidence was doubled over last 20 years. Althought the number of cases is increasing, there is still no effective way for their diagnostics or treatment. With development of implantology, there are still common bacterial diseases as a result of formation of bacterial biofilms on unnatural surfaces. The development of synthetic nucleases which could prevent formation of biofilms is therefore one of the scientific aims. The aim of this bachelor thesis is preparation of polyazamacrocycles which contain amino and amidic functional groups. It can be assumed that these compounds will deprotonate amidic groups after coordination of copper(II) ion. These systems are designed to serve as agents for diagnostics of neurodegenerative diseases using positron emission tomography. In addition, as the complexes are coordinatively unsaturated, they can potentially show an artificial nucleases activity and ability to hydrolytically cleave bacterial biofilms.
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Theoretical and Methodological Issues in the Evidence Production in the Addictology.
Petruželka, Benjamin ; Barták, Miroslav (advisor) ; Kuchař, Pavel (referee) ; Mojžíšová, Adéla (referee)
Background: Indicators, primarily administrative indicators, the field of addiction studies are considered imperfect, approximate and associated with a number of issues. Among others, these issues are based in the fact that administrative indicators are not primarily research indicators. In spite of their shortcomings, these indicators are an important part of public policy making, as they are part of strategic documents and can be used to assess the situation and develop policies in the field of addictive substances. Objectives: The first objective of this thesis was to identify issues related to the administrative indicators. The second objective was to propose the directions for development in areas that had been identified as problematic, i.e., the theoretical and methodological framework. The third objective was to apply selected procedures that had been proposed in the previous parts of the thesis. Methods: To meet the first objective, the basic issues associated with the use of administrative indicators were identified using a narrative review of the literature. The directions for the development of the theoretical and methodological framework were elaborated, responding to the issues identified in the review. The third objective was achieved by application of the approaches described in the...
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