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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Molecular aberrations in testicular germ cell tumors and their significance in tumor pathogenesis and clinical practice
 Matoušková, Laura ; Boublíková, Ludmila (advisor) ; Vymetálková, Veronika (referee)
Testicular germ cell tumors (TGCT) are rare in general but they are also the most commonly occuring malignant tumors in adolescent and young males. Predispositions for the incidence of TGCT include genetic factors - a number of discovered DNA risk loci, epigenetic changes in DNA, alterations of various signaling pathways and also external environmental risk factors. These tumors usually respond to cisplatine therapy very well, nevertheless some patients develop a resistance to this cytostatic medicament. There is still relatively small amount of research dedicated to the cause of cisplatine resistance, as well as to bio-molecular characteristics of TGCT and their role in the pathogenesis. As a result, there is only a little development in TGCT therapy to this day and thus there is no targeted therapy available, which would be highly effective for treating patients with developed cisplatine resistance and/or poor prognosis of their disease. As a result of the fact that TGCT incidence is increasing in the recent decades, it can be considered an actual problem requiring urgent addressing in order to improve the survival rate and quality of life of patients with advanced TGCT. Theoretical part of this thesis deals with the main currently known molecular characteristics of TGCT as well as cisplatine...
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Age estimation from human biological material based on DNA methylation
 Matoušková, Laura ; Kulichová, Iva (advisor) ; Priehodová, Edita (referee)
DNA methylation is one of the epigenetics modifications which performs many functions in human body by silencing genes and maintaining genomic stability. Changes in DNA methylation accumulate during life and current studies indicate that the level of methylation in certain loci (CpG dinucletotides) correlates with chronological age. However, the methylation pattern changes not only with increasing age but it can also be affected by our lifestyle choices and biogeographical origin. Therefore, the key for succesful age estimation is finding such CpG loci that are independent (or as little dependent as possible) on other variables. This bachelor thesis describes the issue of age estimation based on DNA analysis of specific methylated DNA loci with focus on its application in forensic practice.
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See also: similar author names
22 MATOUŠKOVÁ, Lenka
19 MATOUŠKOVÁ, Lucie
22 Matoušková, Lenka
4 Matoušková, Leona
19 Matoušková, Lucie
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