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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Expression of G-protein Dexras1 in the rat suprachiasmatic nucleus.
 Marschnerová, Tereza ; Bendová, Zdeňka (advisor) ; Ostašov, Pavel (referee)
The main mammalian circadian oscillators, suprachiasmatic nuclei (SCN), are stored in the hypothalamus along the third ventricle. They are responsible for time synchronization of behavioral and physiological processes in the body. The endogenous period and phase are controlled by rhythmic changes in the external environment, especially by changing of light and darkness. The light pulse during the night activates NMDA type glutamate receptors, neuronal NO synthase kinase and MAPK ERK1 / 2. This signaling pathway affects the transcription of clock genes and thus the mechanism generating circadian oscillations. Protein Dexras1 acts as a nucleotide exchanger monomer and heterotrimer Gi/o protein and is considered a connecting link between the activation of NMDA glutamate receptor agonist, nNOS signaling and phosforylation of ERK1 / 2. It is rhythmically expressed in the suprachiasmatic nucleus and its genetic deletion leads to abnormal light synchronization.This may indicate its role in the signaling cascade that results in the information concerning the light pulse from the retina to the SCN. The aim of this thesis was to describe the expression of mRNA and protein Dexras1 in the development of the rat suprachiasmatic nuclei and correlate it with the maturation mechanism of light synchronization. Our...
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