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Feasibility and Clinical Value of Vena Contracta Area in the Quantification of Functional Mitral Regurgitation During Bicycle Exercise: A Color Doppler 3D Echocardiography Study
Večeřa, Jan ; Malý, Radovan (advisor) ; Hutyra, Martin (referee) ; Paleček, Tomáš (referee)
The utility of three-dimensional (3D) colour Doppler echocardiography for the evaluation of dynamic changes of secondary mitral regurgitation during dynamic stress echocardiography Previous studies proved, that severe functional mitral regurgitation (FMR) at rest and/or its significant increase during exercise have been shown to be associated with reduced functional capacity and impaired prognosis. In these studies, FMR has been assessed using 2- dimensional (D) quantitative techniques: proximal isovelocity surface (PISA) and pulsed Doppler volumetry. These methods, however, have several known limitations. Recently, color Doppler 3-D echocardiography-derived vena contracta cross-sectional area (VCA) has emerged as a new method to assess FMR severity at rest. VCA at rest has been shown to have higher correlation with the 2-D integrative method or magnetic resonance-derived regurgitant volume than any single 2-D method. The prognostic significance of VCA at rest and its increase during exercise, however, has not been investigated. Therefore, the goal of our study was 1) to find out if the the relationship between exercise-induced changes of FMR assessed by VCA, clinical and Doppler characteristics is different from previous PISA derived ERO based studies, 2) to find resting predictors of exercise-induced...
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