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Hystopathological Changes of Ascending Aorta and Serum Concentration of Transforming Growth Factor in Patients with Proven Aortopathy
Karalko, Mikita ; Pojar, Marek (advisor) ; Špaček, Miroslav (referee) ; Kurfirst, Vojtěch (referee)
- ENG Histopathological changes of ascending aorta and serum concentration of transforming growth factor in patients with proven aortopathy The etiology of ascending aorta dilation in patients with nonsyndromic ascending aortic aneurysm is not clearly defined and may be multifactorial. Haemodynamic or genetic factors are involved. Determination of the etiology and eventual markers of progression of aortic wall dilatation is important because it is the etiology that determines the risk of catastrophic vascular complications, such as aortic dissection (AD). However, publications on this topic are scarce and their results are contradictory. A total of 376 patients from the clinical database of our institution were included in the retrospective analysis. These patients underwent either elective surgery for dilatation of the ascending aorta (DAA) or emergency surgery for AD. This was an isolated procedure on the ascending aorta or in combination with an aortic valve procedure. After excision, samples of the ascending aorta were histologically examined. On histological examination, we found significantly higher degree of involvement in samples from patients with TAV compared with patients with BAV (P <0.001). However, the correlation was weak for all variables when aortic diameter and histological...
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Cardiac care for the elderly - health and social aspects
KURFIRST, Vojtěch
Cardivascular diseases are still the major cause of mortality and morbidity in developped countries. From the available demographic datas ageing of population connected with increased number of patients is evident. These cardiovascular patients are treated conservative, interventional and surgical way. In the theoretical part of this work characteristics and patophysiology of ageing is described regarding particular body systems. Then there are mentioned individual diseases of heart which are currently being treated in a surgical way. It mainly deals with ischemic heart disease, disease of aortic, mitral and tricuspid valve and supraventricular arrythmia. There is also a desrciption of pre-operative preparation, course of the surgery and early postoperative period as well as pharmacological and interventionist therapy. Attention is paid to the differences in surgical care about seniors ? determination of operation risk, pre-operative course, operative course and postoperative rehabilitation. Quality of life is also mentioned as the important aspect while evaluating the success rate of treatment of the particular disease. The work gives information about its definition, possibilities of its observing and evaluation during the postoperative period. Last but not least social issues of senior patients are mentioned in the work as well. The research part is focused on the evaluation of the patients´ state during the pre-operative, perioperative and postoperative period. Particular associated diseases, data from the surgery and postoperative complications are also recorded. The research part then deals with the confirmation of individual hypothesis which were performed through the questionnaires before and one year after the surgery. It was answered by 310 patients.
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