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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Subretinal implantation of a carrier for retinal pigment epithelium in minipigs
 Straňák, Zbyněk ; Kuchynka, Pavel (advisor) ; Mahelková, Gabriela (referee) ; Rusňák, Štěpán (referee)
Age-related macular degeneration (AMD) is the leading cause of practical blindness in developed countries. AMD is one of many retinal diseases that arise from the absence and/or dysfunction of the retinal pigment epithelium (RPE). There are two main types of VPMD (wet and dry), which differ in etiopathogenesis and ophthalmological findings. To date, therapy is only possible for the wet form of AMD, where neovascularization permeating from the choroid and subsequent oozing or bleeding in the subretinal space with deterioration of rod and cone cells and other neuronal cells occurs. Neovascularization can be partially prevented by repeated intra-vitreal applications of anti-VEGF agents. Without treatment, the result is a disciform retinal scar and irreversible visual impairment. A current trend in the treatment of AMD is the attempt to introduce innovative surgical procedures that have the potential to improve severe ophthalmic morbidity, particularly in non-responders to pharmacological therapy. The aim of this study was to evaluate the success rate and optimize a surgical procedure that allows for controlled and safe transplantation of RPE cells. The success of transplantation of RPE cells in the form of an epithelium that acts as a selective barrier immediately after transplantation is dependent on the...
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Path antigen recognition and immune response after orthotopic transplantation cornea in a mouse model
 Netuková, Magdaléna ; Kuchynka, Pavel (advisor) ; Filipec, Martin (referee) ; Rozsíval, Pavel (referee) ; Slavčev, Antonij (referee)
The present work deals with analysis of cell subpopulations in normal mouse cornea and the expression of specific markers of these cells. Another goal of this work was to monitor the origin and function of immune cells infiltrating fibrin mesh in the anterior chamber after orthotopic corneal transplantation.
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5 Kuchynka, Petr
5 Kuchyňka, Petr
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