|
|
A study of the properties of tablets made of three types of microcrystalline cellulose.
Koreňová, Michaela ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
THE STUDY OF TABLETS' PROPERTIES FROM THREE TYPES OF MICROCRYSTALLINE CELLULOSE SUMMARY The thesis deals with the study of properties of tablets from three type of directly compressible microcrystalline cellulose, namely Microcel® MC-102 SP, Microcel® MC-122 and Microcel® MC-250. The focus of the study was the dependence of tensile strength and disintegration time of the tablets on the compression force, the addition of 0,5% lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv), and addition of 50% model drugs, namely acetylsalicylic acid and ascorbic acid. The compression forces were used 3, 4 and 5 kN, compacts containing the drugs were compressed only with a force of 5 kN. The strength of tablets from all three types Microcels increased with increasing compression force, the presence of the lubricant resulted in a decrease in the strength. The compacts of Microcel MC-102 SP had similar tensile strenght like the compacts of Microcel MC-122, while the tensile strenght of compacts of Microcel MC-250 was lower. The greatest and smallest decline of tensile strenght due to the lubricant effect was recorded for Microcel MC-122 and Microcel MC-102 SP respectively. The lubricants shortened disintegration time of all Microcels. The longest disintegration time had the tablets of Microcel MC-102...
|
|
|
A study of the properties of tablets made of three types of microcrystalline cellulose.
Koreňová, Michaela ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
THE STUDY OF TABLETS' PROPERTIES FROM THREE TYPES OF MICROCRYSTALLINE CELLULOSE SUMMARY The thesis deals with the study of properties of tablets from three type of directly compressible microcrystalline cellulose, namely Microcel® MC-102 SP, Microcel® MC-122 and Microcel® MC-250. The focus of the study was the dependence of tensile strength and disintegration time of the tablets on the compression force, the addition of 0,5% lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv), and addition of 50% model drugs, namely acetylsalicylic acid and ascorbic acid. The compression forces were used 3, 4 and 5 kN, compacts containing the drugs were compressed only with a force of 5 kN. The strength of tablets from all three types Microcels increased with increasing compression force, the presence of the lubricant resulted in a decrease in the strength. The compacts of Microcel MC-102 SP had similar tensile strenght like the compacts of Microcel MC-122, while the tensile strenght of compacts of Microcel MC-250 was lower. The greatest and smallest decline of tensile strenght due to the lubricant effect was recorded for Microcel MC-122 and Microcel MC-102 SP respectively. The lubricants shortened disintegration time of all Microcels. The longest disintegration time had the tablets of Microcel MC-102...
|
guest ::
RSS feed.