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A study of the properties of compacts from various types of directly compressible xylitol.
Komínková, Hana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The thesis deals with the study of properties of tablets from two types of directly compressible xylitol, namely Xylitab® 100 and Xylitab® 200. The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv), with a concentration of 1%, and a 50% addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid. The compression forces used were 6, 8, and 10 kN; tablets containing the drugs were only compressed with a force of 10 kN. The tensile strength of tablets from both dry binders increased with increasing compression force; the presence of the lubricants resulted in a slight decrease in the strength. The tensile strength of tablets from Xylitab® 100 was higher and more affected by the lubricants than that of tablets from Xylitab® 200. The disintegration time of tablets was longer in the case of tablets with Xylitab® 200; it increased with increasing compression 9. Souhrn 82 force, with the exception of Xylitab® 200 with magnesium stearate, and was prolonged by the lubricants, more by magnesium stearate. Tablets containing either of the drugs showed a higher tensile strength and a shorter disintegration time when Xylitab®...
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A study of the properties of compacts from various types of directly compressible xylitol.
Komínková, Hana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The thesis deals with the study of properties of tablets from two types of directly compressible xylitol, namely Xylitab® 100 and Xylitab® 200. The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv), with a concentration of 1%, and a 50% addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid. The compression forces used were 6, 8, and 10 kN; tablets containing the drugs were only compressed with a force of 10 kN. The tensile strength of tablets from both dry binders increased with increasing compression force; the presence of the lubricants resulted in a slight decrease in the strength. The tensile strength of tablets from Xylitab® 100 was higher and more affected by the lubricants than that of tablets from Xylitab® 200. The disintegration time of tablets was longer in the case of tablets with Xylitab® 200; it increased with increasing compression 9. Souhrn 82 force, with the exception of Xylitab® 200 with magnesium stearate, and was prolonged by the lubricants, more by magnesium stearate. Tablets containing either of the drugs showed a higher tensile strength and a shorter disintegration time when Xylitab®...
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A study of the properties of tablets from the mixture of directly compressible xylitol and microcrystalline cellulose.
Komínková, Hana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Název v anglictine: A study of the properties of tablets from the mixture of directly compressible xylitol and microcrystalline cellulose. Summary: The thesis deals with the study of properties of tablets from a mixture of directly compressible xylitol, namely Xylitab® 300, and microcrystalline cellulose, namely Microcel® MC-12, in the ratio of 1:1. (This ratio was arrived at after preceding experiments concerning the strength of tablets made only from Xylitab® 300, and from a mixture of Xylitab® 300 and Microcel® MC-12 in the ratio of 3:1. The strength was insufficient in these cases.) The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv®), with concentrations of 0.5% and 1%, and a 50% addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid. The compression forces used were 10, 12.5, and 15 kN; tablets containing the drugs were only compressed with a force of 15 kN. Tablets with a weight of 0.5 g and a diameter of 13 mm were compressed using material testing machine T1-FRO 50 TH.A1K Zwick/Roell and they were further subjected to a strength test using Schleuniger Tablet Tester 8M and to a disintegration time test...
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