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Cholestatic Liver Disease in a Rat Model and the Possibilities for its Control
Kohoutek, Lukáš ; Kaška, Milan (advisor) ; Gürlich, Robert (referee) ; Vokurka, Jan (referee)
Cholestatic liver disease in a rat model and the possibilities for its control Cholestatic liver disease is accompanied with oxidave stress. That it the reason why decreases antioxidative capacity of liver and increases leaky gut. It causes endotoxemia and expansion of production of cytokines and then forming multiorgan failure. Statins can be the way to protect liver cause of their anti-inflammatory efects. Aims: Aims of this study was to verify effect of statines. The questions are if the statin can be medicament which could prevent to increase of liver disease. The reason of this it will be in the oxidative and inflammatory damage, and if may depent on the time of filling statines and dose of statine. Methods: We have defined four groups of rats. We compared between the rats with laparotomy and with or without ligation of choledochus and with taking fluvastatin or not. We rated the tissue of liver and blood sample, or serum. We rated the degree of demage of liver tissue, the degree of cholestasis and proteosyntetic function of the liver. The rating of effects of fluvastatin depends on quantity of the dose (1 and 5 mg/kg of body weight) and the time of dosing of fluvastatin (1 and 2 weeks). Next scale in the studying of processing in cholestatic liver tissues is studium of mechanism of effects...
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Moral content and influence of Christian sexual ethics manuals
Kohoutek, Lukáš ; Lorman, Jaroslav (advisor) ; Ovečka, Libor (referee)
The present dissertation on the topic of The Moral content and influence of Christian manuals on sexual ethics opens with the definitions of key terms and the establishment of a methodology for a sample SWOT analysis of the chosen texts. First, the current state of scientific knowledge of human sexuality is charted both within the sphere of natural sciences and the humanities. Next, the teachings of the Magisterium on sexuality in marriage are presented, evaluated and finally confronted with the findings of modern sciences. In this way, a complex view of human sexuality both "from below" and "from the top" emerges. A SWOT analysis of manuals on sexual ethics, modified for the purpose of this study, has been carried out based on these findings. The output of the analysis suggests a potential influence of the contents and forms of these texts on their readers. The study concludes with a formulation of several recommendations, which might contribute not only to the improvement of the quality of the handbooks but, more importantly, also to the improvement of the relationship of young people to the positive teachings of the Church on human sexuality.
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