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National Repository of Grey Literature 1 records found  Search took 0.02 seconds. 
Hepatocyte transplantation in acute liver failure in experiment
 Koblihová, Eva ; Ryska, Miroslav (advisor) ; Urbánek, Petr (referee) ; Liška, Václav (referee)
Acute liver failure (ALF) is life-threatening disease with high mortality rate. Orthotopic liver transplantation is the only effective therapy but it is limited with scarcity of donor organs. Other methods are searching for as bridging therapy. Transplantation of hepatocytes seems to be a promising method. We have chosen the chemical model of acute liver failure caused by intraperitoneal (i.p.) application of thioacetamide (TAA) in rats. We wanted to investigate the course of ALF when induced by increasing doses of TAA, ranging from 175 to 700 mg/kg of body weight i.p. per day. Plasma levels of albumin, bilirubin, alanine aminotransferase and aspartate aminotransferase activities and ammonia levels and survival rate were determined. We also examined whether Wistar and Lewis rats exhibit any differences in the course of ALF in response to increasing TAA doses. Our data show that Wistar rats are more susceptible to developing TAA-induced ALF than Lewis rats. In the other part we focused on hepatocyte transplantation in ALF. TAA was administrated i.p. in two injections, in the total amount of 525 mg/kg of body weight. After this dose all Lewis rats developed ALF and without treatment succumbed within first 48 h. Hepatocyte were isolated from transgenic male rat luc-Lwe-Tg in two step collagenase...
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