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Support for gifted primary school pupils in the Kolín district
Křížková, Věra ; Krčmářová, Tereza (advisor) ; Krátká, Jana (referee)
The diploma thesis deals with the system of support for gifted pupils in elementary schools with an emphasis on the 1st grade of elementary schools. The aim of the work is to help pedagogues to better understand this issue. The aim of the theoretical part of the work is to describe, based on the available knowledge from the professional literature, how the identification and support of gifted pupils should take place. The theoretical part characterizes the gifted student, defines the concept of giftedness, describes the basic models of giftedness, the typology and manifestations of gifted students, and describes the possibilities of working with gifted students. Furthermore, the theoretical part of the thesis analyzes individual legislative measures and school policy documents that describe the education of gifted pupils in the Czech Republic. The work characterizes the participating system of support for gifted students and their mutual cooperation. The goal of the research investigation was to answer the question of how the education of gifted elementary school pupils in the Kolín district is carried out. For data collection, a questionnaire survey method was used among teachers of the 1st grade of primary schools and among members of the management of primary schools. The following method was a...
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Nodal and Extranodal Lymphomas: Clinicopathological, Immunohistochemical, Molecular-Biological Charactersistics
Veselá, Pavla ; Boudová, Ludmila (advisor) ; Křížková, Věra (referee) ; Křen, Leoš (referee)
3 Abstract The doctor thesis is composed of two major studies, both of them focused on the mantle cell lymphoma (MCL). The first part deals with the verification of the prognostic influence of Mantle Cell Lymphoma International Prognostic Index (MIPI) and of the proliferative activity in 235 patients with MCL diagnosed in 1996-2008 in the Czech Republic. This population study was performed in the collaboration with the Czech Lymphoma Study Group. The clinical data of patients were completed in April 2012. The diagnosis of MCL was confirmed by our central histopathologic examination of pretherapeutic histological samples. The median overall survival (OS) was 47 months, median progression free survival (PFS) was 22 months. We demonstrated the influence of proliferative activity, MIPI and of the therapy type (intensive/non-intensive) on OS and PFS in univariate and multivariate analysis. Using univariate analysis we showed the prognostic influence of aggressive/other cytomorphological variants of MCL, nodal/extranodal localization of primary sample and also of the variants of MIPI - s-MIPI, MIPIb and a completely new variant of MIPI - combined MIPI. The prognostic influence of growth pattern and of the results of immunohistochemical reaction with CD23, CD5 and cyclin D1 antibodies were not confirmed. The other...
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Nodal and Extranodal Lymphomas: Clinicopathological, Immunohistochemical, Molecular-Biological Charactersistics
Veselá, Pavla ; Boudová, Ludmila (advisor) ; Křížková, Věra (referee) ; Křen, Leoš (referee)
3 Abstract The doctor thesis is composed of two major studies, both of them focused on the mantle cell lymphoma (MCL). The first part deals with the verification of the prognostic influence of Mantle Cell Lymphoma International Prognostic Index (MIPI) and of the proliferative activity in 235 patients with MCL diagnosed in 1996-2008 in the Czech Republic. This population study was performed in the collaboration with the Czech Lymphoma Study Group. The clinical data of patients were completed in April 2012. The diagnosis of MCL was confirmed by our central histopathologic examination of pretherapeutic histological samples. The median overall survival (OS) was 47 months, median progression free survival (PFS) was 22 months. We demonstrated the influence of proliferative activity, MIPI and of the therapy type (intensive/non-intensive) on OS and PFS in univariate and multivariate analysis. Using univariate analysis we showed the prognostic influence of aggressive/other cytomorphological variants of MCL, nodal/extranodal localization of primary sample and also of the variants of MIPI - s-MIPI, MIPIb and a completely new variant of MIPI - combined MIPI. The prognostic influence of growth pattern and of the results of immunohistochemical reaction with CD23, CD5 and cyclin D1 antibodies were not confirmed. The other...
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