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Optimisation of Preparation of Nanoparticles from Branched Polyesters with Terbinafine
Königová, Eliška ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate: Mgr. Eliška Königová Consultant: Doc. RNDr. Milan Dittrich, CSc. Title of Thesis: Optimisation of preparation of nanoparticles from branched polyesters with terbinafine The theoretical part of the thesis describes methods of microencapsulation and nanoencapsulation of drugs into polymeric carriers with a particular emphasis on nanoparticular systems from copolymers of lactic and glycolic acids. Experimental part of the thesis focuses on formulation and testing of particles from terpolymer of DL-lactic acid, glycolic acid and tripentaerythritol characterised by a branched molecular structure. The particles were prepared by using of emulsion distribution and evaporation method. Terbinafine and cetrimide hydrobromide was incorporated into the particles. Cetrimide hydrobromide in very low concentrations in water solution was also used as an emulsifying agent, which adjusts properly surface charge. Polyhydric compounds such as mannitol, trehalose and mannose were used in emulsion outer phase as a stabilising agent. Granulometric characteristics, mainly Z-average of intensity diameter of microparticles and nanoparticles, also particle size distribution, and their polydispersity were...
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Influence of solvent on the size of polyester nanoparticles
Königová, Eliška ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra farmaceutické technologie Studentka: Eliška Königová Vedoucí diplomové práce: Doc. RNDr. Milan Dittrich CSc. Název práce: Influence of solvent on the size of polyester nanoparticles In the theoretical part of this thesis the methods of fabrication of nanoparticles and their evaluation are described. It further explores the biodegradable polymer of glycolic acid and lactic acid and in particular the nanoparticles prepared from this polymer. The main objective were the results of an experiment which explored some of the technological parameters of formulation of biodegradable particles made from terpolymer of DL-lactic acid, glycolic acid and tripentaerythritole by o/w emulsion method. The aim was to create the smallest possible nanoparticles using the standard procedure. The study sought the optimal concentration of emulsifier cetrimide. It evaluated the influence of the concentration of emulsion and the concentration of the polyester carrier and terbinafine as a model drug for the assessment of granulometric parameters of prepared particles. For an intended use of the method the storage of samples at low temperature after the addition of mannitol was granulometrically evaluated.
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Optimisation of Preparation of Nanoparticles from Branched Polyesters with Terbinafine
Königová, Eliška ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate: Mgr. Eliška Königová Consultant: Doc. RNDr. Milan Dittrich, CSc. Title of Thesis: Optimisation of preparation of nanoparticles from branched polyesters with terbinafine The theoretical part of the thesis describes methods of microencapsulation and nanoencapsulation of drugs into polymeric carriers with a particular emphasis on nanoparticular systems from copolymers of lactic and glycolic acids. Experimental part of the thesis focuses on formulation and testing of particles from terpolymer of DL-lactic acid, glycolic acid and tripentaerythritol characterised by a branched molecular structure. The particles were prepared by using of emulsion distribution and evaporation method. Terbinafine and cetrimide hydrobromide was incorporated into the particles. Cetrimide hydrobromide in very low concentrations in water solution was also used as an emulsifying agent, which adjusts properly surface charge. Polyhydric compounds such as mannitol, trehalose and mannose were used in emulsion outer phase as a stabilising agent. Granulometric characteristics, mainly Z-average of intensity diameter of microparticles and nanoparticles, also particle size distribution, and their polydispersity were...
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