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Biofluid biomarkers of Alzheimer's disease and Lewy body disease and their relationship with cognitive and structural markers
 Jurášová, Vanesa ; Veverová, Kateřina (advisor) ; Chmátalová, Zuzana (referee)
The diagnosis of Alzheimer's disease is based on the determination of specific proteins in cerebrospinal fluid (CSF) or their imaging using positron emission tomography. Both methods are invasive and can expose the patient to risk and discomfort. Blood biomarkers, therefore, represent hope for early diagnosis and monitoring of individuals at increased risk of developing Alzheimer's disease. The diploma thesis aimed to determine biomarkers in blood using the ultrasensitive Simoa TM (Single molecular assay) technology and to verify their relationship to the values in CSF. The second aim was to track the relationship between blood biomarkers and cognitive markers of Alzheimer's disease. We demonstrated a positive relationship between serum, plasma, and CSF p-tau 181 concentrations. A negative correlation was observed between the concentrations of p-tau 181 in blood and the results of the MMSE test, which is considered a standard cognitive assessment tool. These findings suggest that plasma and serum p-tau 181 may greatly help the clinical identification of neurodegenerative diseases in primary care. The negative correlation of plasma and serum p-tau 181 with MMSE test results suggests that blood p-tau 181 could be used in population-based studies to detect individuals at high risk of developing...
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