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Properties of branched oligoesters plasticized using 20 % of triethyl citrate
Jiráková, Irena ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
The aim of this graduation theses objective was the study of adhesions and rheologic properties of branched oligoesters and acyclovir release from these carriers. The experimental part introduces main targets for the mucoadhesion, natural and synthetic bioadhesives, their functions and properties. And further more there is the mucoadhesion in gastrointestinal tract and oral cavity with some examples of polymers and dosage forms. The practical part is regarded to the testing of dynamic viscosity and adhesion of the oligoesters of lactic and glycolic acid branched using dipentaerythrotol (0,5D, 1D, 2D, 3D, 5D, 8D) and linear PLGA. These oligoesters were plasticized by 20% of triethylcitrate. The acyclovir release from carriers 0,5D, 1D and 2D was studed. The dynamic viscosity was the highest by carriers 3D and 0,5D. The highest adhesion power was measured out by carriers 0,5D and PLGA. The longest period time of release was by carrier 2D, twenty-one days. The most fast aciclovir release was measured regarding to carrier 0,5 D, two days. Then 1D, seven days. Keywords: bioadhesion, adhesive polymers, viscosity, acyclovir release
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Properties of branched oligoesters plasticized using 20 % of triethyl citrate
Jiráková, Irena ; Dittrich, Milan (referee) ; Šnejdrová, Eva (advisor)
The aim of this graduation theses objective was the study of adhesions and rheologic properties of branched oligoesters and acyclovir release from these carriers. The experimental part introduces main targets for the mucoadhesion, natural and synthetic bioadhesives, their functions and properties. And further more there is the mucoadhesion in gastrointestinal tract and oral cavity with some examples of polymers and dosage forms. The practical part is regarded to the testing of dynamic viscosity and adhesion of the oligoesters of lactic and glycolic acid branched using dipentaerythrotol (0,5D, 1D, 2D, 3D, 5D, 8D) and linear PLGA. These oligoesters were plasticized by 20% of triethylcitrate. The acyclovir release from carriers 0,5D, 1D and 2D was studed. The dynamic viscosity was the highest by carriers 3D and 0,5D. The highest adhesion power was measured out by carriers 0,5D and PLGA. The longest period time of release was by carrier 2D, twenty-one days. The most fast aciclovir release was measured regarding to carrier 0,5 D, two days. Then 1D, seven days. Keywords: bioadhesion, adhesive polymers, viscosity, acyclovir release
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