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Upgrade of extruder head for 3D bioprinting of thermolabile hydrogels
Kedroň, Kryštof ; Harabiš, Vratislav (referee) ; Jaroš, Josef (advisor)
3D bioprinting is a perspective method of tissue engineering, capable of creating tissue structures with physiological function and spatial arrangement. The thesis deals with the use of this method for printing thermolabile hydrogels. The main goal of the thesis is to extend the print head for 3D printing of thermolabile hydrogels. The theoretical part is devoted to the description of 3D bioprinting, especially the important properties that each material must meet to be able to print, there is also a review of used hydrogels in bioprinting, focusing on thermolabile, print modalities, the possibility of cooling the printhead and a description of the ideal equipment for printing of thermolabile hydrogels. The practical part deals with the design and realization of the print head for 3D printing of thermolabile hydrogels, in the last part the achieved results are evaluated and discussed.
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Model Study of Ultrasound Effects on Fetal Development
Jaroš, Josef ; Halámek, Josef (referee) ; Hrazdíra,, Ivo (referee) ; Rozman, Jiří (advisor)
The progress in ultrasound techniques goes hand in hand with increasing of diagnostic machine acoustic outputs. Ultrasound biological effects can adversely influence the development of human fetus. Recent studies of thermal effect on biological tissues are usually based on simulation of simple ultrasound transducers. The aim of this work is to build a flexible model of diagnostic system to simulate temperature increase during fetal development. Different types of ultrasound probes were used for generation of acoustic field with simulated piezoelectric element properties. Optimized linear and phased arrays were modeled with dynamic beam steering and focus. Computer simulations were concentrated on extreme conditions in obstetric ultrasonography and 3D tissue model was compared with real ultrasound probes measurements. To detect temperature increase, the bone tissue phantom was used. Results point out potential risks for fetus with diagnostic ultrasound probes. Based on the results of this work, practical recommendations increasing safety of obstetric examinations were drawn.
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SOCIETY AND THE CHURCH IN THE FORMER WESTERN ROMAN EMPIRE IN THE 5TH TO THE 7TH CENTURY
Jaroš, Josef ; Veverková, Kamila (advisor)
The thesis titled "Society and Church within the Territory of the Former Western Roman Empire in the 5th to 7th century AD" focuses on relations between the society and the church, specifically within territories which, at the given period, formed the Western Roman Empire (5th century AD) and its successor states (6th to 7th century AD). The given period was chosen as it marked a turning point in the relations between the state, or the society, and the church; the further development in Europe, not limited to religion, stems from this period. The 5th century represents a sort of a prologue to the dramatic and turbulent 6th century, while the 7th century is an afterpiece during which the details of the further direction and development of the Catholic Church were refined. The aim of my thesis was to confirm or disconfirm the hypotheses that Christianity (the church) did not accelerate the fall of the Western Roman Empire or that it did not significantly contribute to it, that it was not a bearer of progress as it did not improve the general conditions, and that the church had the character of any religion serving power and was not unique in any way at the time. Attention is paid initially to political and economic situation, which is followed by the study of the relationships between the church and the...
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Upgrade of extruder head for 3D bioprinting of thermolabile hydrogels
Kedroň, Kryštof ; Harabiš, Vratislav (referee) ; Jaroš, Josef (advisor)
3D bioprinting is a perspective method of tissue engineering, capable of creating tissue structures with physiological function and spatial arrangement. The thesis deals with the use of this method for printing thermolabile hydrogels. The main goal of the thesis is to extend the print head for 3D printing of thermolabile hydrogels. The theoretical part is devoted to the description of 3D bioprinting, especially the important properties that each material must meet to be able to print, there is also a review of used hydrogels in bioprinting, focusing on thermolabile, print modalities, the possibility of cooling the printhead and a description of the ideal equipment for printing of thermolabile hydrogels. The practical part deals with the design and realization of the print head for 3D printing of thermolabile hydrogels, in the last part the achieved results are evaluated and discussed.
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SOCIETY AND THE CHURCH IN THE FORMER WESTERN ROMAN EMPIRE IN THE 5TH TO THE 7TH CENTURY
Jaroš, Josef ; Veverková, Kamila (advisor)
The thesis titled "Society and Church within the Territory of the Former Western Roman Empire in the 5th to 7th century AD" focuses on relations between the society and the church, specifically within territories which, at the given period, formed the Western Roman Empire (5th century AD) and its successor states (6th to 7th century AD). The given period was chosen as it marked a turning point in the relations between the state, or the society, and the church; the further development in Europe, not limited to religion, stems from this period. The 5th century represents a sort of a prologue to the dramatic and turbulent 6th century, while the 7th century is an afterpiece during which the details of the further direction and development of the Catholic Church were refined. The aim of my thesis was to confirm or disconfirm the hypotheses that Christianity (the church) did not accelerate the fall of the Western Roman Empire or that it did not significantly contribute to it, that it was not a bearer of progress as it did not improve the general conditions, and that the church had the character of any religion serving power and was not unique in any way at the time. Attention is paid initially to political and economic situation, which is followed by the study of the relationships between the church and the...
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SOCIETY AND THE CHURCH IN THE FORMER WESTERN ROMAN EMPIRE IN THE 5TH TO THE 7TH CENTURY
Jaroš, Josef ; Veverková, Kamila (advisor) ; Lášek, Jan Blahoslav (referee)
The thesis titled "Society and Church within the Territory of the Former Western Roman Empire in the 5th to 7th century AD" focuses on relations between the society and the church, specifically within territories which, at the given period, formed the Western Roman Empire (5th century AD) and its successor states (6th to 7th century AD). The given period was chosen as it marked a turning point in the relations between the state, or the society, and the church; the further development in Europe, not limited to religion, stems from this period. The 5th century represents a sort of a prologue to the dramatic and turbulent 6th century, while the 7th century is an afterpiece during which the details of the further direction and development of the Catholic Church were refined. The aim of my thesis was to confirm or disconfirm the hypotheses that Christianity (the church) did not accelerate the fall of the Western Roman Empire or that it did not significantly contribute to it, that it was not a bearer of progress as it did not improve the general conditions, and that the church had the character of any religion serving power and was not unique in any way at the time. Attention is paid initially to political and economic situation, which is followed by the study of the relationships between the church and the...
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Signaling mechanism in nuclear reorientation and its functional singnificance in cell migration.
Maninová, Miloslava ; Vomastek, Tomáš (advisor) ; Hodný, Zdeněk (referee) ; Jaroš, Josef (referee)
The establishment of cellular polarity is first critical step of directional cell migration. The process of cellular polarization requires many signaling pathways that are differently regulated at the cell front and at the rear side and enables creation of typical asymmetrical profile of migrating cell. During the polarization cell forms the leading edge and trailing rear and relocalizes the intracellular organelles to such a position that is optimal for directional movement. In many migrating cells cell nucleus is usually located at the cell rear and microtubule organizing center localizes between the nucleus and the leading edge of the cell. This cellular arrangement is prerequisite for directional cell migration. We have shown that during cell polarization cell also reorients the nucleus to the direction of migration. The nuclear reorientation is temporally restricted rotation of the cell nucleus that aligns the longer nuclear axis with the axis of migration. Nuclear reorientation promotes the establishment of cellular polarity and facilitates the movement of the cell. The nuclear reorientation requires the physical linkage of the nucleus to cell cytoskeleton mediated by LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We have shown that LINC complex anchors the nucleus to actin stress...
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Model Study of Ultrasound Effects on Fetal Development
Jaroš, Josef ; Halámek, Josef (referee) ; Hrazdíra,, Ivo (referee) ; Rozman, Jiří (advisor)
The progress in ultrasound techniques goes hand in hand with increasing of diagnostic machine acoustic outputs. Ultrasound biological effects can adversely influence the development of human fetus. Recent studies of thermal effect on biological tissues are usually based on simulation of simple ultrasound transducers. The aim of this work is to build a flexible model of diagnostic system to simulate temperature increase during fetal development. Different types of ultrasound probes were used for generation of acoustic field with simulated piezoelectric element properties. Optimized linear and phased arrays were modeled with dynamic beam steering and focus. Computer simulations were concentrated on extreme conditions in obstetric ultrasonography and 3D tissue model was compared with real ultrasound probes measurements. To detect temperature increase, the bone tissue phantom was used. Results point out potential risks for fetus with diagnostic ultrasound probes. Based on the results of this work, practical recommendations increasing safety of obstetric examinations were drawn.
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