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Evaluation of tensile strength of tablets containing theophylline
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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Study of flow and consolidation behaviour of pharmaceutical free-flowable excipients
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Mgr. Hana Janoutová Title of Thesis: Study of flow and consolidation behaviour of pharmaceutical free-flowable excipients Flowability is an important characteristic of pharmaceutical powders that affects processing of the powder. Flow and granulometric properties of mannitol (Pearlitol® 200 SD, Pearlitol® 400 DC) and xylitol (Xylisorb® XTAB 240, Xylisorb® XTAB 400) were evaluated in this thesis. The angle of repose was measured by an automatic tester Erweka and a prototype complying with ASTM standards for the determination of angle of repose. Hopper orifices having a diameter 6 mm, 8 mm, 10 mm, 12 mm, and 15 mm were used to study the influence of the orifice diameter on the value of angle of repose. Determination of angle of repose was completed with the measurement of density of a formed pile. The values of angle of repose measured by the Erweka tester were higher in all samples than those obtained from the prototype. For both apparatuses, the angle of repose decreased with increasing in the orifice diameter.
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Evaluation of tensile strength of tablets containing theophylline
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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