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Biocompatible polymer systems for medical application
Hrochová, Michaela ; Etrych, Tomáš (advisor) ; Bárta, František (referee)
Polymer carriers for drug delivery are still an extensively studied topic in many research laboratories around the world. Polymer systems have an important role in the case of oncological diseases, where they allow to increase the therapeutic effect and significantly reduce the side effects of treatment. The present thesis is primarily focused on the synthesis of novel water-soluble biodegradable polymer systems based on N-(2- hydroxypropyl)methacrylamide enabling the treatment of solid tumors. As part of the work, four bifunctional transfer agents have been developed, which enable the direct synthesis of symmetric diblock polymers with a size of 20,000-100,000 g∙mol-1 with RAFT polymerization. The transfer agents introduce hydrolytically labile ester bonds into the structure of diblock polymers, which allow the diblock to break down into smaller fragments that can be excreted by the kidneys. The different structures of the chain transfer agents make it possible to control the breakdown of diblocks over a wide time range from 2,5 hours to 21 days. The advantages of the prepared diblock carriers are primarily the one-step synthesis, adjustable degradation time, and the possibility of modifying the end groups of the polymer chain. In the presence of bifunctional transfer agents, copolymers of HPMA...
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Biodegradable polymer carriers with structure tailored for increased tumor tissue permeability
Hrochová, Michaela ; Etrych, Tomáš (advisor) ; Sedláček, Ondřej (referee)
Cancer diseases are the most common cause of death over the world. One fifth of death is caused by cancer in the Czech Republic. The big problem in the treatment of cancer diseases are side effects of chemotherapy, which make treatment more difficult for patients. The present bachelor thesis is focused on synthesis and characterization of novel polymer carriers. Polymer carriers can target the cytostatic drug to the tumor tissue and minimize side-effect of chemotherapies. This bachelor thesis is focused on synthesis and physical chemistry characterization of new diblock polymer carriers, specifically carries of docetaxel. Successful synthesis of novel water-soluble polymer precursors and conjugates based on N-(2-hydroxypropyl)- methacrylamide is described and discussed in this thesis. The hydrolytic stability of the synthesized diblock systems was studied in 0,3M phosphate buffer at pH 7,4 simulating the bloodstream environment. It has been successfully verified that the synthesized polymer systems are hydrolytically degradable after fulfilling its role of drug carrier and therefore can be finally excreted from the organism. The effect of the type of oxoacid used for modification of the cytostatic on the release rate of the carried cytostatic from the polymeric carriers was thoroughly evaluated and...
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