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Determination of pharmaceuticals in wastewaters
Horkelová, Simona ; Sobotníková, Jana (advisor) ; Coufal, Pavel (referee)
The issue of pharmaceutical accumulation in the environment is a pressing concern today. Annually, the consumption and misuse of pharmaceuticals increase, with a significant portion ultimately being discharged into wastewater. Unfortunately, wastewater treatment processes often prove inadequate in effectively removing these substances, as they were not originally designed for this purpose. Consequently, pharmaceuticals gradually infiltrate water systems, resulting in heightened pollution of surface water, groundwater, and even drinking water sources. Due to insufficient legislation, there is a need for stricter monitoring and elimination of pharmaceutical substances containing. This master's thesis investigates the presence of pharmaceuticals and some metabolites in wastewater samples using an accredited method at ALS Czech Republic laboratory. It compares the input and output concentrations of drugs in wastewater treatment plants of varying sizes and assesses the efficacy of their removal. Additionally, it contrasts municipal sewage treatment plants serving communities with hospital wastewater treatment plants. Key words: LC-MS, pharmaceuticals, metabolites, wastewaters, environment
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Synthesis of new nucleosides as potential inhibitors of flaviviral replication
Horkelová, Simona ; Nencka, Radim (advisor) ; Janeba, Zlatko (referee)
Viruses of the Flaviviridae family are the causative agents of many dangerous diseases for which we currently have no known cure, and research into new drugs against them therefore represents one of the major challenges for modern medicinal chemistry. Targeting the proteins encoded by viruses is the most common approach to combat them. For flaviviruses, the non- structural protein NS5 exhibiting methyltransferase (MTase) and RNA-dependent-RNA polymerase (RdRp) enzyme activity appears to be one of the most suitable molecular targets. This bachelor thesis deals with the synthesis of new potential drugs capable of inhibition skill of flaviviral RdRp. C-nucleoside analogues were prepared, containing 2 types of heterocyclical base: 3-fluoropicolamide modified in positions 5 or 6 and pyrido[3,2-d]pyrimidine-4-amine modified in positions 6 or 7 using aryl or heteroaromatic substituent Key words: C-nucleosides, polymerase, flaviviruses, Tick-borne encephalitis virus, Suzuki reaction, Grignard reaction
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