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Assessment of the Efficacy of Photodynamic Therapy in Patients with Chronic Central Serous Chorioretinopathy
Myslík Manethová, Kateřina ; Jirásková, Naďa (advisor) ; Hejsek, Libor (referee) ; Chrapek, Oldřich (referee)
Assessment of the efficacy of photodynamic therapy in patients with chronic central serous chorioretinopathy The presented postgraduate thesis deals with the issue of macular edema based on central serous chorioretinopathy (CSC) and the current possibilities of therapeutic solution of this disease. Although in most cases central serous chorioretinopathy does not belong to frequent and vision-threatening diseases, it can, especially its chronic form, lead to impaired vision. The aim of the theoretical part of this work is to characterize this chorioretinal disease and describe the basic principles of treatment. The work also describes the pathogenesis of CSC, the examination methods, the up-to-date accepted CSC classification and the therapeutic modalities of the treatment of the disease. The clinical part of this work is a prospective study of 52 patients (54 eyes), aged 30- 75, with chronic form of central serous chorioretinopathy treated at the Eye Clinic of the 1st Faculty of Medicine of Charles University and Military University Hospital Prague in the years 2012 to 2018. The aim of this prospective study is to evaluate the anatomical and functional results of the treatment of 54 eyes with chronic form of central serous chorioretinopathy using photodynamic therapy in a reduced (half) dosing...
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Monitoring of the impact of modern surgical procedures on the central portion of retina using electrophysiological methods
Hejsek, Libor ; Langrová, Hana (advisor) ; Boguszaková, Jarmila (referee) ; Těšínský, Pavel (referee)
Monitoring of the impact of modern surgical procedures on the central portion of retina using electrophysiological methods. Libor Hejsek We evaluate annual anatomical and functional results of 20G pars plana vitrectomy for idiopathic macular hole, with peeling of the membrana limitans interna and instillation of gas tamponade (20% SF6). The observed group consisted of 32 eyes of 32 patients (3 men and 29 women), mean age 69 years (range 59-76). Objectification of ocular anatomy was done with: anterior segment slit lamp, the biomicroscopy in artificial mydriasis and optical coherence tomography (Stratus OCT ™, Carl Zeiss). Function of the central area of the retina was evaluated: the best corrected visual acuity in the distance (BCVA) with ETDRS optotype, multifocal electroretinography (mfERG) and pattern reversal electroretinography (PERG). For the statistical processing of results we used non-parametric Wilcoxon paired test. Anatomical results: the primary closure of the IMD occurred in 29 (90%), the IMD was not closed, but it's edges were flattened in 2 eyes (6%). Functional results: the visual acuity improved by 2 or more lines in 27 eyes (84%), of 3 or more lines in 18 eyes (56%), and 4 or more lines in 5 eyes (16%). PERG results did not have significant difference. Statistically significant difference...
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