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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Hospital Hradec Králové - comparison of the histochemical results of estrogen and progesterone receptors in the breast tumours with the other tumour markers.
 Pezlarová, Zuzana ; Kovařík, Miroslav (advisor) ; Hadži Nikolov, Dimitar (referee)
In the theoretical part of the work we briefly discuss about composition of the breast, general questions about carcinogenesis in this localization and some of the features of the breast cancer. Below we show in several statistical data. We describe diagnostic order from first contact of the patient with doctor to time of the determination of definitive diagnosis. We mention basic principles of morphological classification of the tumors as well as international classification of the tumors published by World Health Organization, basic rules how to define staging, grading, prognostic and predictive markers of the breast cancer. We concentrate on determination of these five tumor markers: estrogen and progesterone receptors, protein HER-2/neu, proliferation marker Ki-67, and tumor suppresor protein p53. We explain value of examination those markers for later on use for hormonal and biological treatment. Today routine is to do examination of hormonal receptors (estrogen and progesterone) and onkoprotein HER-2/neu to every patient with invasive breast cancer. The other markers such as proliferation marker Ki-67 and expression of the protein p53 help us to predict prognosis of the ilness. In the practical part we shortly describe process of the tissue examination with standard histological technique and...
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Optimalization of the methodical repertoire for laboratory diagnostics of autoimmune diseases of the thyroid gland
 Hadži Nikolov, Dimitar ; Nožička, Zdeněk (advisor) ; Horáček, Jaroslav (referee) ; Habanec, Boris (referee)
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