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Pharmacological and physiological characteristics of organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs)
Gregorová, Pavla ; Štaud, František (advisor) ; Čečková, Martina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Pavla Gregorová Supervisor: Prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Pharmacological and physiological characteristics of organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) Abstract: Membrane transporters are important and life-enabling proteins of the body, which facilitate the absorption, distribution, and elimination of nutrients, metabolic waste products, drugs, and xenobiotics. Multidrug and toxin extrusion proteins (MATEs) and organic cation transporters (OCTs) belong to polyspecific transporters of the solute carrier (SLC) family and form a cooperating system of excretion in the kidney and liver. The transporters are expressed in many tissues throughout the body primarily in the kidneys, liver, heart, brain, small intestine, and placenta and transmit countless molecules from the natural neurotransmitters and hormones to exogenous compounds, such as metformine, cimetidine, 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA) or acyclovir. Furthermore, there are described the most recent studies in knockout mice models and genetic polymorphisms that help identify transporters activity and pharmacokinetics with altered...
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Issues in education of officials of territorial self-governing units in Ostrava
Gregorová, Pavla ; Čebišová, Taisia (advisor) ; Ochrana, František (referee)
This diploma thesis deals with the education of officials of public administration on the level of territorial self-government. The aim of this diploma thesis is to evaluate a system of education of officials of territorial self-governing units on example of a particular town district authority in Ostrava, to identify problematic spheres and to propose the possibilities of their solution. After introductory determination of the problem in the beginning of the thesis there are theoretical solutions stated and there are contemporary trends of development in education of officials in Europe outlined. Afterwards there is an origin of contemporary system of education of officials of territorial self-governing units in the Czech Republic described in the context of reform of public administration which is followed by the determination of legislative framework, by organisation of education and by overview of participants engaged in this sphere. In empirical part of the thesis there is a research of education of officials at the town district authority in Ostrava implemented and the results of the research including identification of problematic spheres are compared with results of similar researches. There are proposals and recommendations /leading to increase in efficiency of education of officials at...
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Pharmacological and physiological characteristics of organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs)
Gregorová, Pavla ; Štaud, František (advisor) ; Čečková, Martina (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Pavla Gregorová Supervisor: Prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Pharmacological and physiological characteristics of organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) Abstract: Membrane transporters are important and life-enabling proteins of the body, which facilitate the absorption, distribution, and elimination of nutrients, metabolic waste products, drugs, and xenobiotics. Multidrug and toxin extrusion proteins (MATEs) and organic cation transporters (OCTs) belong to polyspecific transporters of the solute carrier (SLC) family and form a cooperating system of excretion in the kidney and liver. The transporters are expressed in many tissues throughout the body primarily in the kidneys, liver, heart, brain, small intestine, and placenta and transmit countless molecules from the natural neurotransmitters and hormones to exogenous compounds, such as metformine, cimetidine, 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA) or acyclovir. Furthermore, there are described the most recent studies in knockout mice models and genetic polymorphisms that help identify transporters activity and pharmacokinetics with altered...
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Issues in education of officials of territorial self-governing units in Ostrava
Gregorová, Pavla ; Čebišová, Taisia (advisor) ; Ochrana, František (referee)
This diploma thesis deals with the education of officials of public administration on the level of territorial self-government. The aim of this diploma thesis is to evaluate a system of education of officials of territorial self-governing units on example of a particular town district authority in Ostrava, to identify problematic spheres and to propose the possibilities of their solution. After introductory determination of the problem in the beginning of the thesis there are theoretical solutions stated and there are contemporary trends of development in education of officials in Europe outlined. Afterwards there is an origin of contemporary system of education of officials of territorial self-governing units in the Czech Republic described in the context of reform of public administration which is followed by the determination of legislative framework, by organisation of education and by overview of participants engaged in this sphere. In empirical part of the thesis there is a research of education of officials at the town district authority in Ostrava implemented and the results of the research including identification of problematic spheres are compared with results of similar researches. There are proposals and recommendations /leading to increase in efficiency of education of officials at...
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