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Nanocarriers for dermal and transdermal drug administration
Girgel, Josef ; Zbytovská, Jarmila (advisor) ; Holas, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Josef Girgel Consultant: Doc. Dr. rer. Nat. Mgr. Jarmila Zbytovská Title of thesis: Nanocarriers for dermal and transdermal drug delivery The aim of this work was to map the literature and the most logically divide it and to elucidate the mechanisms of the carrier's interaction with the skin, the degree of their ability to penetrate the skin and to evaluate their potential to the next years. Skin administration appears to be more advantageous way than others, mainly due to higher patient's compliance, avoiding the first pass effect of the liver, ensuring a stable blood concentration during transdermal administration and reducing adverse effect of the drug. However, the skin serves as an effective barrier to the external environment, especially its outermost layer called stratum corneum. In a recent year, the interest of many research groups has focused on nanocarriers which are expected to deliver more efficient transport to and through the skin barrier due to their size ranging from tens to hundreds of nanometers. It has been confirmed that some of these carriers are able to permeate the skin. For metallic nanoparticles, their permeation is primary associated with toxicity and they are...
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