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Identification of new biomarkers and target molecules for the comprehensive treatment (drug-target) via proteomic analysis of body fluids and tissues experimental study
Fremuth, Jiří ; Kobr, Jiří (advisor) ; Nosáľ, Slavomír (referee) ; Hoza, Jozef (referee) ; Slavík, Zdeněk (referee)
The main objective of our prospective experimental study was to develop a clinically relevant model of mechanical ventilation of healthy and damaged lungs ventilated for 12 hours. A widely recommended Vt=6ml/kg was used in comparison with commonly used Vt=10ml/kg. The study included a total of 52 piglets of domestic pig (Sus scrofa f. domestica) age 5-9 weeks. Piglets were divided into 3 groups: group B - Vt = 6ml/kg (11 piglets, 8 died), group C - Vt = 10ml/kg (21 piglets, 5 died) and group D - Vt= 50 ml + instillation of 50 ml saline into the trachea (6 piglets, 1 died). In the presented study we focused on the influence of mechanical ventilation on several organ systems as well as induction of systemic inflammatory reaction. By using higher tidal volume, we aimed to induce possible biotraumatic changes. The ventilator settings were deliberately not changed during the study, except the change of Fi02 values based on the Sp02 value. The first goal was to assess the influence of two different strategies of mechanical ventilation and induced lung injury on respiratory functions of the lungs and pulmonary mechanics. Piglets ventilated with Vt = 6ml/kg maintain the physiological oxemia, but the level of capnia increased over time with an adequate effect on acid-base balance. The highest mortality in...
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Identification of new biomarkers and target molecules for the comprehensive treatment (drug-target) via proteomic analysis of body fluids and tissues experimental study
Fremuth, Jiří ; Kobr, Jiří (advisor) ; Nosáľ, Slavomír (referee) ; Hoza, Jozef (referee) ; Slavík, Zdeněk (referee)
The main objective of our prospective experimental study was to develop a clinically relevant model of mechanical ventilation of healthy and damaged lungs ventilated for 12 hours. A widely recommended Vt=6ml/kg was used in comparison with commonly used Vt=10ml/kg. The study included a total of 52 piglets of domestic pig (Sus scrofa f. domestica) age 5-9 weeks. Piglets were divided into 3 groups: group B - Vt = 6ml/kg (11 piglets, 8 died), group C - Vt = 10ml/kg (21 piglets, 5 died) and group D - Vt= 50 ml + instillation of 50 ml saline into the trachea (6 piglets, 1 died). In the presented study we focused on the influence of mechanical ventilation on several organ systems as well as induction of systemic inflammatory reaction. By using higher tidal volume, we aimed to induce possible biotraumatic changes. The ventilator settings were deliberately not changed during the study, except the change of Fi02 values based on the Sp02 value. The first goal was to assess the influence of two different strategies of mechanical ventilation and induced lung injury on respiratory functions of the lungs and pulmonary mechanics. Piglets ventilated with Vt = 6ml/kg maintain the physiological oxemia, but the level of capnia increased over time with an adequate effect on acid-base balance. The highest mortality in...
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The impacts of keeping quality and safety systems of crop production on the price of final product
Fremuth, Jan ; Tomášek, Jaroslav (advisor) ; Ondřej, Ondřej (referee)
The thesis deals with the issue of compliance processes to ensure safety and quality of food. These standards are embedded in the world's standards, the standards.
In the introduction, the author explains the reason for the choice of this topic. Further hypotheses and objectives formulated by the work that have to be met and verified. From the available literature was created glossary topic, where I describe the history of the topic, its evolution and the current status at the present time. In the next chapter the author verifies the formulated hypotheses and meets the objectives of the work, all on the basis of the specified methods. At the conclusion of the work the author confronts the detected results with findings from the available literature, with hypotheses, review, and outlined the future continuation of the thesis.
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Betula - komplexní výzkum břízy jako náhradní dřeviny v Krušnohoří: Fauna nosatcovitých (Curculionoidea) v porostech imisní oblasti LS Sněžník
Univerzita Palackého v Olomouci, Pedagogická fakulta, Olomouc ; Mendelova zemědělská a lesnická univerzita v Brně, Lesnická a dřevařská fakulta, Brno ; Stejskal, R. ; Majzlan, O. ; Fremuth, J. ; Kula, Emanuel
Nosatcovití jsou vysoce početnou skupinou fytofágů ve fauně porostů břízy, jejichž škodlivost není dostatečně prostudována. Bionomie, fenologie, populační dynamika nosatcovitých nejsou dostatečně prostudovány a cílem zprávy je na základě patnáctiletých systematických sběrů s uplatněním různých kontrolních metod zhodnotit druhové spektrum nosatcovitých v oblasti LS Sněžník (nyní LS Děčín) především v porostech břízy, jejich populační dynamiku, fenologii líhnutí, sezónní aktivitu a význam pro břízu.
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