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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Neuroactive steroids in human physiology and pathophysiology
 Kubátová, Jana ; Hill, Martin (advisor) ; Fanta, Michal (referee)
The present diploma thesis is focused on the evaluation of steroid metabolome in body fluids in human pregnancy and parturition and also concentrates on the estimation of steroids in men with epilepsy (MWE) regarding the influence of epilepsy and its treatment with antiepileptic drugs (AEDs). The results obtained eventuate to the following conclusions: 1. They support the proposition about the key importance of corticoliberin for the timing of human parturition via stimulation of the steroidogenesis in the fetal zone of the fetal adrenal (FZ). Changes in steroid levels, however, much better predict the timing of parturition than the variation in corticoliberin. 2. The distribution of isoforms of placental oxidoreductases determines the excess of oxidized forms of the sex steroids and NAS in the fetus and the excess of their reduced forms in mother. This mechanism fundamentally affects the steroid bioactivity. The results indicate the role of NAS in pregnancy sustaining, their analgesic effect around parturition and their role in the pathophysiology of postpartum blues.
Detailed record
Methodology of implementing a recommender system using the Soyka tool
 Müller, Petr ; Gála, Libor (advisor) ; Fanta, Michal (referee)
This diploma thesis is focused on content personalization and specifically on recommender systems. The aim of the thesis is to propose a methodology of recommender system implementation in e-commerce using the IT tool Soyka. Functions of personalization tools which directly support recommender systems are identified on the basis of a theoretical description of recommender systems and their technological approaches. Based on these identified functions the tool Soyka is classified. The main contribution of the thesis is the created and published methodology which is ready to be used on real implementation projects by anyone involved.
Detailed record
Neuroactive steroids in human physiology and pathophysiology
 Kubátová, Jana ; Hill, Martin (advisor) ; Fanta, Michal (referee)
The present diploma thesis is focused on the evaluation of steroid metabolome in body fluids in human pregnancy and parturition and also concentrates on the estimation of steroids in men with epilepsy (MWE) regarding the influence of epilepsy and its treatment with antiepileptic drugs (AEDs). The results obtained eventuate to the following conclusions: 1. They support the proposition about the key importance of corticoliberin for the timing of human parturition via stimulation of the steroidogenesis in the fetal zone of the fetal adrenal (FZ). Changes in steroid levels, however, much better predict the timing of parturition than the variation in corticoliberin. 2. The distribution of isoforms of placental oxidoreductases determines the excess of oxidized forms of the sex steroids and NAS in the fetus and the excess of their reduced forms in mother. This mechanism fundamentally affects the steroid bioactivity. The results indicate the role of NAS in pregnancy sustaining, their analgesic effect around parturition and their role in the pathophysiology of postpartum blues.
Detailed record

See also: similar author names
3 Fanta, Martin
1 Fanta, Matěj
2 Fanta, Michael
2 Fanta, Miroslav
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