|
|
Molecular biomarkers of solid tumors and their use in prognosis and prevention of cancer
Elsnerová, Kateřina ; Václavíková, Radka (advisor) ; Fiala, Ondřej (referee) ; Vymetálková, Veronika (referee)
Molecular biomarkers of solid tumors and their use in prognosis and prevention of cancer Molekulární biomarkery solidních nádorů a jejich využití v prognóze a prevenci nádorových onemocnění Mgr. Kateřina Elsnerová Summary Malignant tumors of ovary and breast are among the most widespread cancers in women. Despite improvements in diagnostics and in therapy, mortality is still very high. An important tool for early cancer detection, as well as for monitoring prognosis and preventing progression, are molecular biomarkers; biomarkers were the topic of this work. The aim of this work was to find out (i) whether there are differences in gene expression between tumor and non-tumor tissues, and among controls (C), primary tumors (pT) and intraperitoneal metastases (iM), respectively; (ii) whether gene expression or genetic variants (single nucleotide polymorphisms, DNA methylation, germline mutations) associate with clinical data of patients, thus being potentially relevant for prognosis. In epithelial ovarian cancer (EOC), 50 of 94 genes were deregulated in controls compared to tumors. Fifteen of 66 genes were deregulated in intraperitoneal metastases compared to primary tumors. Gene expression of ABCA7, ABCB2, ABCC3, ESR2, NH1H4 and NR1I1 was deregulated either in comparison of primary tumors and metastases, or...
|
guest ::
