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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Evalution of DNA Damage and Repair in patients with Non-small Cell Lung Cancer Due to Drug Therapy with Platinum Derivatives
 Fikrová, Petra ; Hronek, Miloslav (advisor) ; Herink, Josef (referee) ; Dušinská, Mária (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Biological and Medical Sciences Candidate: Mgr. Petra Fikrová Supervisor: Doc. PharmDr. Miloslav Hronek, Ph.D. Consultant: Prof. RNDr. Rudolf Štětina, CSc. Title of doctoral thesis: Evaluation of DNA damage and repair in patients with non-small cell lung cancer due to drug therapy with platinum derivatives Lung cancer is the most common worldwide cause of cancer-related death. This type of cancer is divided into two subtypes, the small cell and non-small cell lung cancer. Platinum- based chemotherapy is the mainstay of treatment of advanced stages non-small cell lung cancer, to that is this work focused on. The aim of this study was to investigate whether it is possible to use the comet assay method for monitoring the progress of treatment in these patients, and if it is possible to predict a patient's response to treatment or patient's survival. Standard version or modifications of comet assay were used for the measurement of DNA damage or oxidative DNA damage and we also validated a modification of comet assay for measuring DNA crosslinks. This evaluation was carried out either in vitro in HeLa cells and in peripheral blood lymphocytes from healthy donors from Transfusion department of University Hospital in Hradec...
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Evalution of DNA Damage and Repair in patients with Non-small Cell Lung Cancer Due to Drug Therapy with Platinum Derivatives
 Fikrová, Petra ; Hronek, Miloslav (advisor) ; Herink, Josef (referee) ; Dušinská, Mária (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Biological and Medical Sciences Candidate: Mgr. Petra Fikrová Supervisor: Doc. PharmDr. Miloslav Hronek, Ph.D. Consultant: Prof. RNDr. Rudolf Štětina, CSc. Title of doctoral thesis: Evaluation of DNA damage and repair in patients with non-small cell lung cancer due to drug therapy with platinum derivatives Lung cancer is the most common worldwide cause of cancer-related death. This type of cancer is divided into two subtypes, the small cell and non-small cell lung cancer. Platinum- based chemotherapy is the mainstay of treatment of advanced stages non-small cell lung cancer, to that is this work focused on. The aim of this study was to investigate whether it is possible to use the comet assay method for monitoring the progress of treatment in these patients, and if it is possible to predict a patient's response to treatment or patient's survival. Standard version or modifications of comet assay were used for the measurement of DNA damage or oxidative DNA damage and we also validated a modification of comet assay for measuring DNA crosslinks. This evaluation was carried out either in vitro in HeLa cells and in peripheral blood lymphocytes from healthy donors from Transfusion department of University Hospital in Hradec...
Detailed record

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