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Identification of DNA sequence binding C/EBP and C/EBPb proteins involved in RANKL expression
Dušek, Lukáš ; Křivčíková, Lucie (advisor) ; Konečná, Klára (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Lukáš Dušek Supervisor: Ing. Lucie Křivčíková, Asist. Vid Mlakar, B. Sc. microbial., Ph.D. Thesis title: Identification of DNA sequence binding C/EBP and C/EBPb proteins involved in RANKL expression Bone thinning - osteoporosis - is an increasing problem of human health worldwide. Johnell and Kanis estimated that in 2000 more than 9.0 million of osteoporotic fractures occurred - this means about 3 fractures from osteoporosis every second [1]. Because the decrease in bone mineral density (BMD) is associated with age and with the aging of the world population, the issue of bone health and especially osteoporosis is expected to emerge in its urgency. Discovery of osteoprotegerin (OPG) / receptor activator of nuclear factor kappa-B (RANK) / RANK-ligand (RANKL) pathway in late 90' gave scientists a fruitful target for future investigations about bone metabolism and revealed interesting interconnections with cardiovascular diseases, immunity and cancer survival and targeting. This study had one experimental and two theoretical goals: The experimental and primary goal was to identify transcription factors and DNA binding sites in -662 to -438 region upstream of RANKL transcription start...
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Identification of DNA sequence binding C/EBP and C/EBPb proteins involved in RANKL expression
Dušek, Lukáš ; Křivčíková, Lucie (advisor) ; Konečná, Klára (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Lukáš Dušek Supervisor: Ing. Lucie Křivčíková, Asist. Vid Mlakar, B. Sc. microbial., Ph.D. Thesis title: Identification of DNA sequence binding C/EBP and C/EBPb proteins involved in RANKL expression Bone thinning - osteoporosis - is an increasing problem of human health worldwide. Johnell and Kanis estimated that in 2000 more than 9.0 million of osteoporotic fractures occurred - this means about 3 fractures from osteoporosis every second [1]. Because the decrease in bone mineral density (BMD) is associated with age and with the aging of the world population, the issue of bone health and especially osteoporosis is expected to emerge in its urgency. Discovery of osteoprotegerin (OPG) / receptor activator of nuclear factor kappa-B (RANK) / RANK-ligand (RANKL) pathway in late 90' gave scientists a fruitful target for future investigations about bone metabolism and revealed interesting interconnections with cardiovascular diseases, immunity and cancer survival and targeting. This study had one experimental and two theoretical goals: The experimental and primary goal was to identify transcription factors and DNA binding sites in -662 to -438 region upstream of RANKL transcription start...
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Domestic arbitration proceedings in Czech Republic
Dušek, Lukáš ; Winterová, Alena (advisor) ; Smolík, Petr (referee)
The diploma thesis deals with domestic arbitration proceedings in the Czech Republic. The topic has been chosen by the author because the arbitration could have a big potential as it is a mechanism which is well adaptable to individual needs of parties. During last few years it has became evident that the arbitration is being abused by some subjects and the substantive law protection of some subject is circumvented by arbitration. Thus, the reputation of arbitration has been damaged. The aim of the thesis is to examine eventual limits of application of domestic arbitration, the possibilities of abusing it and law tools aiming to protect against the abusing. In the introduction the author's opinion is introduced stating why the domestic arbitration is different from international arbitration. The author notes that the traditional mechanism of domestic dispute resolution is court proceedings. The same could not be said about international dispute resolution. Furthermore, the author argues that in international relations there is applied wider autonomy of will of the parties than in domestic relations. Also the bodies acting in international arbitration have significantly better reputation and credibility. There are also not differences between various law orders in domestic relations and the consumer...
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