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Treatment of the recurring chronic wound in diabetes mellitus II.
Drtinová, Blanka ; Semecký, Vladimír (advisor) ; Šimkovič, Dušan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Science Candidate: Blanka Drtinová Supervisor: Doc. RNDr. Vladimír Semecký, CSc. Title of diploma thesis: Treatment of the recurring chronic wound in diabetes mellitus II. Diabetes mellitus is a heterogeneous group of diseases. The main characteristic of this disease is hyperglycemia. During diabetes the patient develops microvascular and macrovascular complications. These complications lead to lower quality of patient's life and are the reasons for frequent hospitalisation and high mortality rates of diabetes patients. Wound healing physiologically includes phases of hemostasis, inflammation, proliferation and remodelation. For chronic wounds is a typical extension of the inflammation phase. The basic approach in treating chronic wounds is to ensure optimal environment in the wound and its surroundings. This includes removing pressure on the ulcer, debridement, local therapy, treating the infection and ischemia. When choosing suitable treatment, localisation, compensation, and cause of the ulceration have to be considered. Patient has to be educated. It is therefore essential to see each patient as an individual and choose treatment method suitable for the individual. Unsuccessful therapy leads...
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Treatment of the recurring chronic wound in diabetes mellitus II.
Drtinová, Blanka ; Šimkovič, Dušan (referee) ; Semecký, Vladimír (advisor)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Science Candidate: Blanka Drtinová Supervisor: Doc. RNDr. Vladimír Semecký, CSc. Title of diploma thesis: Treatment of the recurring chronic wound in diabetes mellitus II. Diabetes mellitus is a heterogeneous group of diseases. The main characteristic of this disease is hyperglycemia. During diabetes the patient develops microvascular and macrovascular complications. These complications lead to lower quality of patient's life and are the reasons for frequent hospitalisation and high mortality rates of diabetes patients. Wound healing physiologically includes phases of hemostasis, inflammation, proliferation and remodelation. For chronic wounds is a typical extension of the inflammation phase. The basic approach in treating chronic wounds is to ensure optimal environment in the wound and its surroundings. This includes removing pressure on the ulcer, debridement, local therapy, treating the infection and ischemia. When choosing suitable treatment, localisation, compensation, and cause of the ulceration have to be considered. Patient has to be educated. It is therefore essential to see each patient as an individual and choose treatment method suitable for the individual. Unsuccessful therapy leads...
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The report on a development of advanced methods of the study of speciation and description of sorption of actinoids
Vopálka, D. ; Drtinová, B. ; Motl, A. ; Šebera, Jakub ; Štamberg, K. ; Vetešník, A. ; Višňák, J. ; Zavadilová, A.
The report of the last period of the project presents a development of three topics, each of which relates to the study of the radionuclide migration in fields near to disposal of nuclear waste and other nuclear facilities. The local structure and thermodynamic stability of uranyl sulfate complexes in aqueous solution was investigated by DFT theory. Interpretation of UV-VIS absorption spectra of uranyl-sulfate and -aqua complexes in aqueous solution was performed within the time-dependent DFT calculations. The structures were optimized in the aqueous phase at the B3LYP level by using model COSMO. The calculated geometries of aqua-sulfate complexes corresponded to the experimental data. DFT method described qualitatively thermodynamic stability of complexes in solution. TD-DFT method correctly interpreted only a part of absorption spectra (190-340 nm). In order to interpret the area around 420 nm it will be necessary to use the two-component relativistic TD-DFT.
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