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Economic Efficiency of the Investment Project
Paulus, Adam ; Doubek, Michael (referee) ; Korytárová, Jana (advisor)
The theme of this bachelor´s thesis is assessment of the economic efficiency of public construction investment. The first part is about general problematics of investing, its life cycle and about magical triangle. Description of criterial economic efficiency ratios follows. The last theoretical part contains desription of input-output analysis and description of feasibility study modified for public projects. The practical part describes and calculates efficiency of the specific investment, revitalization of the brownfield to the public library.
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Complex Evaluation of Immune Defects in Patients with Chronic Lymphocytic Leukemia
Vodárek, Pavel ; Belada, David (advisor) ; Doubek, Michael (referee) ; Papajík, Tomáš (referee)
Complex evaluation of immune defects in patients with chronic lymphocytic leukemia MUDr. Pavel Vodárek Abstract of dissertation thesis Chronic lymphocytic leukemia (CLL) is associated with significant combined immunodeficiency. Amongst most important immune defects are hypogammaglobulinemia and changes in relative and absolute counts of different lymphocyte populations and subsets. As consequence of these changes, there can be higher frequency of infections and progression of CLL itself. The impact of chemoimmunotherapy (CIT) on immunoglobulin (Ig) levels and lymphocyte populations has not been extensively studied. In this dissertation thesis, we analysed Ig levels and lymphocyte populations (using flow cytometry) in 45 patients with indolent untreated CLL and 90 patients with progressive disease indicated for treatment. In 58 patients, we evaluated the impact of first-line CIT. For lymphocyte populations' analysis, we had also cohort of 34 healthy controls. Patients with progressive disease had significantly lower levels of all Ig classes and subclasses than patients with inactive disease: IgG, median 6.96 vs. 9.86 g/l, p=0.0001; IgA, median 0.63 vs. 1.53 g/l, p<0.0001; IgM, median 0.36 vs. 0.57 g/l, p=0.0035. After treatment, median IgA increased from 0.59 g/l to 0.74 g/l (p=0.0031). Other Ig classes and...
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Current aspects of care patients with chronic lymphocytic leukemia
Šimkovič, Martin ; Smolej, Lukáš (advisor) ; Doubek, Michael (referee) ; Papajík, Tomáš (referee)
In recent years it has been an unprecedented development of knowledge of biology and treatment options of chronic lymphocytic leukemia (CLL). Survival of patients with CLL was improved by the introduction of the monoclonal antibodies (anti-CD20) and combined chemoimmunotherapy regimens. Despite this undeniable advance in the treatment of CLL and progress in knowledge of CLL biology and pathophysiology, many current aspects of care of these patients remain unresolved. In our work we focus on epidemiology of CLL, treatment of relapsing/refractory CLL patients, rituximab infusion-related adverse events and venous thromboembolism in CLL patients. Incidence of CLL in Hradec Králové district during period 1999-2013 was 8.2 patients per 100,000 persons per year. Trends in epidemiology were analyzed after splitting patients into two groups according to the period in which the diagnosis was made: n=92 in the period 1999- 2005 and n=108 in the period 2006-2013. Significant prolongation of survival (median OS not reached vs 86 months) was observed in patients treated during the period 2006-2013 in comparison to those treated in the period 1999-2005. However, the improvement of overall survival was achieved only in younger patients (≤ 70 years). Patients with refractory CLL have highly unfavourable prognosis....
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Economic Efficiency of the Investment Project
Paulus, Adam ; Doubek, Michael (referee) ; Korytárová, Jana (advisor)
The theme of this bachelor´s thesis is assessment of the economic efficiency of public construction investment. The first part is about general problematics of investing, its life cycle and about magical triangle. Description of criterial economic efficiency ratios follows. The last theoretical part contains desription of input-output analysis and description of feasibility study modified for public projects. The practical part describes and calculates efficiency of the specific investment, revitalization of the brownfield to the public library.
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Current aspects of care patients with chronic lymphocytic leukemia
Šimkovič, Martin ; Smolej, Lukáš (advisor) ; Doubek, Michael (referee) ; Papajík, Tomáš (referee)
In recent years it has been an unprecedented development of knowledge of biology and treatment options of chronic lymphocytic leukemia (CLL). Survival of patients with CLL was improved by the introduction of the monoclonal antibodies (anti-CD20) and combined chemoimmunotherapy regimens. Despite this undeniable advance in the treatment of CLL and progress in knowledge of CLL biology and pathophysiology, many current aspects of care of these patients remain unresolved. In our work we focus on epidemiology of CLL, treatment of relapsing/refractory CLL patients, rituximab infusion-related adverse events and venous thromboembolism in CLL patients. Incidence of CLL in Hradec Králové district during period 1999-2013 was 8.2 patients per 100,000 persons per year. Trends in epidemiology were analyzed after splitting patients into two groups according to the period in which the diagnosis was made: n=92 in the period 1999- 2005 and n=108 in the period 2006-2013. Significant prolongation of survival (median OS not reached vs 86 months) was observed in patients treated during the period 2006-2013 in comparison to those treated in the period 1999-2005. However, the improvement of overall survival was achieved only in younger patients (≤ 70 years). Patients with refractory CLL have highly unfavourable prognosis....
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Cerebral venous thrombosis risk factors and JAK2 mutation
Košťál, Milan ; Dulíček, Petr (advisor) ; Doubek, Michael (referee) ; Krčová, Věra (referee)
Cerebral venous thrombosis risk factors and JAK2 mutation Cerebral venous thrombosis is a rare type of cerebrovascular disease. The widespread use of neuroimaging has aided early diagnosis of CVT and its parenchymal complications. Etiology and natural history of CVT differs from DVT mainly due to different pathophysiologic conditions of sinuses. The main objective of this study was to find out prevalence of genetic and acquired thrombophilic factors and prevalence of JAK2 V617F mutation (typical for myeloproliferative diseases) in CVT patients and discover their relation to prognosis and treatment. Next target of our survey was to identify typical symptoms of CVT and to verify significance of clinical indicators (time to diagnosis, type of therapy, recurrence, recanalization, etc.) and laboratory tests (D-dimers, blood count). Minority of the data were collected as retrospective (5 patients from a hospital in Pardubice, 18 patients from the University hospital in Hradec Králové). Majority of study was prospective; all patients with CVT prior to the starting point of survey were re-evaluated in outpatient department during the study. Healthy controls were recruited from Transfusion department of the University hospital in Hradec Králové We enrolled 64 patients and 70 healthy controls. JAK2 mutation was more...
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Prognostic factors in chronic lymphocytic leukemia
Motyčková, Monika ; Žák, Pavel (advisor) ; Doubek, Michael (referee) ; Papajík, Tomáš (referee)
Prognostic factors in chronic lymphocytic leukemia Introduction: Search for new prognostic markers in order to improve prognostic accuracy and predict clinical outcome at the time of diagnosis has recently become one of the major trends in chronic lymphocytic leukemia (CLL). Aims of the project: Assessment of selected markers of apoptosis and angiogenesis and their potential as new prognostic factors and correlation with conventional and modern prognostic factors and clinical course. Patients and Methods: We evaluated serum levels of tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-ß1) and fibroblast growth factor-2 (FGF-2) using comercially available enzyme-linked immunosorbent assay; furthemore, we quantified expression of type II receptor for transforming growth factor beta (TGFßRII) and type 2 receptor for FGF-2 (FGFR2) on CLL cells using flow cytometry analysis in 75 previously untreated patients with CLL (47 males and 28 females, median age, 65 years, range, 38-82) and healthy donors. Results: We found significantly elevated TNF-α in patients with CLL compared to the control group (p<0.0001); high expression of TNF-α was associated with unfavourable prognosis: significantly higher TNF-α was present in patients with Rai high-risk group compared to low- and...
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