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The Imaging of Brain Pathological Lesions in Systemic Lupus Erythematosus Patients
Podrazilová, Lucie ; Dostál, Ctibor (advisor) ; Hrnčíř, Zbyněk (referee) ; Seidl, Zdeněk (referee)
Objective: Our project study presents the results of measuring the volume of pathological foci in the brain tissue of patients suffering from systemic lupus erytematodes (SLE) with or without neuropsychiatric manifestations (NP). Magnetic resonance (MR) scans of patients with SLE and, in particular, signs of neuropsychiatric involvement show pathological foci in the cerebral white matter. Methods: A total of 53 SLE patients, 29 with signs of neuropsychiatric syndromes (NPSLE), 24 without, and 16 healthy controls underwent prospective volumetric magnetic resonance imaging in a flow attenuated inversion recovery (FLAIR) sequence. The disease activity was expressed in terms of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results: All of the patients in this study were found to have a larger volume of pathological foci in the brain tissue than the healthy controls. The NPSLE subgroup had a larger volume of pathological foci than the SLE patients without NP (p<0.001). The largest volume of such foci was found in patients with a history of cerebrovascular disease (p<0.05). These were also noted for a correlation between the duration of the disease and the period of time elapsed from the onset of the first signs of neuropsychiatric lupus (p<0.01). Correlation with SLEDAI-rated disease activity...
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Prolactin And Systemic lupus erythematosus
Moszkorzová, Ludmila ; Dostál, Ctibor (advisor) ; Pokorný, Jaroslav (referee) ; Hrnčíř, Zbyněk (referee)
Prolactin (PRL) is a polypeptide hormone of 23 kDa molecular weight made up of 199 amino acids, and produced by lactotropes, acidophilic cells of the anterior lobe of the pituitary. PRL is also synthetized in some other parts of the brain and in certain peripheral blood elements. Whether this extra-pituitary PRL, also known as PRL-like hormone, interferes with serum PRL radioimmunoassay (RIA) and whether it also has a feedback effect on PRL secretion in the pituitary, has yet to be elucidated. There is, however, proof of its apocrine and paracrine function of cellular growth factor, a function enhancing mitogenesis and lymphocyte differentiation at the site of inflammation and thereby their own production of yet other mediators and immunomodulators - including interleukines (IL) and growth factors. PRL also directly interferes with the synthesis of some acute-phase proteins in the liver (stimulating, e.g., alpha-2-macroglobulin synthesis). As a result of these discoveries, PRL was classed among immunomodulators, and the hypothesis was advanced of its part in the pathogenesis of autoimmune diseases. The aim of the thesis was to verify the presence of hyperprolactinemia (hyper- PRL) in SLE patients compare to patients with other auto-immune diseases and to healthy controls and to find its association...
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The Imaging of Brain Pathological Lesions in Systemic Lupus Erythematosus Patients
Podrazilová, Lucie ; Dostál, Ctibor (advisor) ; Hrnčíř, Zbyněk (referee) ; Seidl, Zdeněk (referee)
Objective: Our project study presents the results of measuring the volume of pathological foci in the brain tissue of patients suffering from systemic lupus erytematodes (SLE) with or without neuropsychiatric manifestations (NP). Magnetic resonance (MR) scans of patients with SLE and, in particular, signs of neuropsychiatric involvement show pathological foci in the cerebral white matter. Methods: A total of 53 SLE patients, 29 with signs of neuropsychiatric syndromes (NPSLE), 24 without, and 16 healthy controls underwent prospective volumetric magnetic resonance imaging in a flow attenuated inversion recovery (FLAIR) sequence. The disease activity was expressed in terms of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results: All of the patients in this study were found to have a larger volume of pathological foci in the brain tissue than the healthy controls. The NPSLE subgroup had a larger volume of pathological foci than the SLE patients without NP (p<0.001). The largest volume of such foci was found in patients with a history of cerebrovascular disease (p<0.05). These were also noted for a correlation between the duration of the disease and the period of time elapsed from the onset of the first signs of neuropsychiatric lupus (p<0.01). Correlation with SLEDAI-rated disease activity...
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