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Database system for optometrician shops
Dlouhý, Lukáš ; Borská, Eva (referee) ; Kříž, Jiří (advisor)
This thesis deals with creating a suitable database system for an specific existing company that manufactures and sells glasses. The thesis focuses on describing the development of the database system in SQL, HTML, PHP and also on the structuring of the database. It aims to create a database system, which will comply with the company's requirements.
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Analysis of design variables of prestressed concrete structures using optimization algorithms
Dlouhý, Lukáš ; Navrátil, Jaroslav (advisor)
During recent years more and more emphasis has been put on saving and ecological aspects of the civil engineering industry. As the total volume of concrete being produced on our planet is immense (ca 1010 tons per year), the possibility of decreasing it by even a small percentage can bring large savings in material costs, transport and other costs and reduction of CO2 production and other pollution. Therefore, optimal analysis of design variables of concrete structures appears to be of high importance. Optimization is finding the best solution to a given problem. Many disciplines define different optimization problems and it is typically the minimum or maximum value of the objective function that is searched. It is known that mathematical procedures and algorithms to find an optimal structural design are used in practice in mechanical engineering, but the use of these tools in civil engineering is rather exceptional. Generally, scientific works deal with the optimal design of structures only. Finding of an optimal shape and dimensions is usually a question of the engineer’s experience and good “guess”, which is then verified by calculation. There are many reasons explaining why optimization in common practise is used only occasionally. One of them is the absence of proper user friendly software tools which could help within relatively short time available for structural design. Another reason is the complexity of optimization tasks as well as a lot of constraints in civil engineering design codes. Last but not least, the change of design variables of buildings, bridges and structures of special types do not express regular response. This issue is discussed in the submitted work.
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Analysis of design variables of prestressed concrete structures using optimization algorithms
Dlouhý, Lukáš ; Navrátil, Jaroslav (advisor)
During recent years more and more emphasis has been put on saving and ecological aspects of the civil engineering industry. As the total volume of concrete being produced on our planet is immense (ca 1010 tons per year), the possibility of decreasing it by even a small percentage can bring large savings in material costs, transport and other costs and reduction of CO2 production and other pollution. Therefore, optimal analysis of design variables of concrete structures appears to be of high importance. Optimization is finding the best solution to a given problem. Many disciplines define different optimization problems and it is typically the minimum or maximum value of the objective function that is searched. It is known that mathematical procedures and algorithms to find an optimal structural design are used in practice in mechanical engineering, but the use of these tools in civil engineering is rather exceptional. Generally, scientific works deal with the optimal design of structures only. Finding of an optimal shape and dimensions is usually a question of the engineer’s experience and good “guess”, which is then verified by calculation. There are many reasons explaining why optimization in common practise is used only occasionally. One of them is the absence of proper user friendly software tools which could help within relatively short time available for structural design. Another reason is the complexity of optimization tasks as well as a lot of constraints in civil engineering design codes. Last but not least, the change of design variables of buildings, bridges and structures of special types do not express regular response. This issue is discussed in the submitted work.
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HPLC analysis of dexrazoxane and its metabolites
Dlouhý, Lukáš ; Kovaříková, Petra (advisor) ; Kučera, Radim (referee)
High performance liquid chromatography (HPLC) is one of the most used separating methods of instrumental analysis enabling both qualitative and quantitative analysis of substances. Anthracyclines are cytotoxic drugs widely used in clinical practice for treatment of hematological malignancies (leucaemias, lymphoms) and solid tumours (stomach, breast, ovarian cancer). Treatment by these drugs has a serious limiting factor, however. This factor is an anthracycline induced cardiotoxicity, which is caused by hydroxyl radicals and other reactive oxygen forms. The main role in their formation play the complexes with iron. Dexrazoxane is a derivate of bisdioxopiperazine, which is used to reduce the cardiotoxic effect of anthracyclines. It is supposed that it takes effect by the means of its active metabolite ADR-925, which works as a substance chelating iron. This mechanism hinders the iron dependant formation of oxygen radicals. This thesis deals with analysis options of dexrazoxane and its hydrolysis products/metabolites on the stationary phase Ascentis HILIC in conditions compatible with mass spectrometric detection (MS). The best results were achieved in conditions of isocratic elution using mobile phases containing 5 mM ammonium formiate with pH 5 or 7 and acetonitrile in ratio 22:78 (v/v). Mobile...
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Overview of methods used in plant physiology for primary and secondary compounds estimation
Dlouhý, Lukáš ; Tomášková, Ivana (advisor) ; Čepl, Jaroslav (referee)
This bachelor thesis aims to summarize methods used to prove and isolation substances of primary and secondary metabolism of plants. In introduction I described metabolit path ways leading to creation of metabolites and introduced their definitions. In next chapters I pursued closer description of each group and sub-group of metabolites and specified options of their qualitative analysis. In last part I continued to
outline issues of separation methods, instrumental analysis and finaly to experiments. In conclusion I summarized obtained information generaled comparison of each method or their groups. I estimated the trend of analysis for trees and plants.
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Database system for optometrician shops
Dlouhý, Lukáš ; Borská, Eva (referee) ; Kříž, Jiří (advisor)
This thesis deals with creating a suitable database system for an specific existing company that manufactures and sells glasses. The thesis focuses on describing the development of the database system in SQL, HTML, PHP and also on the structuring of the database. It aims to create a database system, which will comply with the company's requirements.
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