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Synthesis of imidazole derivatives with potential antimycobacterial activity
 Cvejn, Daniel ; Klimešová, Věra (advisor) ; Špulák, Marcel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Department of inorganic and organic chemistry Candidate Daniel Cvejn Supervisor Doc. RNDr. Věra Klimešová, CSc. Supervisor specialist Doc. Ing. Filip Bureš, Ph.D. Title of Thesis Synthesis of imidazole derivatives with potential antimycobacterial activity New substances with potential antimycobacterial actvity were predicted on the basis of literature research. The substance library includes 1-[2-(4-nitrophenyl)-1H-imidazol-4(5)- yl]alkanamines with or without CBz (benzyloxycarbonyl) protected alifatic amino group. Some of predicted derivatives were synthetized and minimal inhibition concentration (MIC) were then measured for four strains of Mycobacteria. Activity of predicted effective substances were compared with measured activity of the 1-[2-phenyl-1H-imidazol-4(5)- yl]alkanamines which do not possess nitro group. Structure activity relationships were also discussed. Keywords: imidazole, amines, antimycobacterial activity, Mycobacterium spp.
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