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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
DNA methyltransferase inhibitors and their effect on the activation of genes being of importance to a presentation of the antigen in tumour cells
 Cebová, Magdaléna ; Reiniš, Milan (advisor) ; Poljaková, Jitka (referee)
DNA methylation is one of the epigenetic modulations that can be associated with tumour diseases. DNA methyltransferases act as catalysers of the process of DNA methylation and their inhibition could be used as a possible approach to the therapy of tumours. DNA methyltransferase inhibitors are classified into two groups, nucleoside inhibitors that are incorporated into DNA and subsequently form covalent bonds with DNA methyltransferase, and non-nucleoside inhibitors whose action is limited to inhibiting the catalytic site of the DNA methyltransferase. The first objective of this bachelor thesis was to compare the toxicity of DNA methyltransferase inhibitors in mouse tumour cell lines. The results show that the toxicity of nucleoside inhibitors is much higher (due to their incorporation into the DNA) than that of non-nucleoside inhibitors. The second objective was to compare the effect of DNA methyltransferase inhibitors on the expression of MHC (major histoncompatibility complex) class I glycoproteins on the surface of mouse tumour cells. Reduced expression of MHC class I glycoproteins is known to be one of the mechanisms used by the tumour cells to escape the immune system. Our laboratory has shown that some inhibitors (5-azacytidine) increase the expression of MHC I class molecules in MHC...
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