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Nitric oxide mediated functional effects in the normal and inflamed urinary bladder of the rat
Cabalková, Jana ; Wsól, Vladimír (advisor) ; Kvasničková, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Jana Cabalková Supervisors: Prof. Ing. Vladimír Wsól, Ph.D (Charles University in Prague, Faculty of Pharmacy) Prof. Gunnar Tobin, O.D., Ph.D. (University of Göteborg in Sweden, Sahlgrenska academy) Title of diploma thesis: Nitric oxide mediated functional effects in the normal and inflamed urinary bladder of the rat. Interstitial cystitis (IC) is a condition characterized by a diffuse inflammation. It affects mainly women and the symptoms include beside pain, which is the most significant one, urge and frequency. The etiology and the pathogenesis of IC are, in spite of many years of research, largely unknown. So far, the research has mainly been focused on IC-induced alterations of sensory mechanisms in the micturition reflex arch. The reason to this is that the levels of the sensory nerve activator ATP are significantly increased in patients suffering from IC. However, two other pivotal molecules in IC are nitric oxide (NO) and acetylcholine, which do not only affect the afferent side in the micturition reflex, but also the efferent side. This project focused on the mechanism of the NO effects in the normal and the inflamed rat urinary bladder. The influence of arginine and sodium...
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