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Synthesis of Isozaleplon Studies
Blahovcová, Michaela ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
SYNTHETIC STUDIES CONNECTED WITH THE PREPARATION OF N-[3-(3-CYANOPYRAZOLO[1,5-a]PYRIMIDIN-5-YL)PHENYL]- N-ETHYLACETAMIDE, A ZALEPLON REGIOISOMER Rigorous Thesis Mgr. Michaela Blahovcová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové This thesis is a continuation of my master thesis and further develops the subject of zaleplon impurities. The main subject of the work is the zaleplon regioisomer, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide called isozaleplon, which is the most problematic impurity of zaleplon. The purpose of this thesis was to propose a synthetic way leading to isozaleplon based on the available literature. Then this substance was intended to be used as a standard for determination of this impurity in preparation of zaleplon by various methods. The studied approaches to the isozaleplon synthesis were based on Suzuki- Miyaura cross-coupling reaction of the corresponding boronic acids and/or boronates, mainly with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile. Various methods of preparation of both components are described, as well as approaches based on the final modification of the 5-(3-aminophenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile moiety...
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Vertical Relationships on the Workplace and their Influence on Employee's Work Motivation: Sociology Case Study
Krösslová, Gabriela ; Kuchař, Pavel (advisor) ; Blahovcová, Michaela (referee)
Subject of this bachelor's thesis is "Vertical relationships at the workplace and theirs influence on employee's work motivation". In the theoretical part, I defined key words, such as: Motivation, vertical and horizontal relationships, work sociology etc. I also stated concepts, related to work sociology and motivation. Practical part deals with the qualitative research (case study), which relates to vertical relationships on workplace as one of the key points of work motivation. That research involves and defines possible aspects which have impact on workplace relationships such as communication, supervisor's personality, managing skills and workplace atmosphere. Research was made in company XY. Main target of the research was to determine how is work motivation of employees influenced by quality of the vertical relationships at the workplace. The respondents were asked about above mentioned aspects to determine which aspects are most important for them. With regard to motivation, majority of respondents mentioned importance of good relationship to their supervisor. Next important point is good atmosphere at the workplace, having impact on employee's work motivation. Personality of supervisor and his attitude to subordinates is also one of main points. Supervisor's qualities should be...
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Vertical Relationships on the Workplace and their Influence on Employee's Work Motivation: Sociology Case Study
Krösslová, Gabriela ; Kuchař, Pavel (advisor) ; Blahovcová, Michaela (referee)
Subject of this bachelor's thesis is "Vertical relationships at the workplace and theirs influence on employee's work motivation". In the theoretical part, I defined key words, such as: Motivation, vertical and horizontal relationships, work sociology etc. I also stated concepts, related to work sociology and motivation. Practical part deals with the qualitative research (case study), which relates to vertical relationships on workplace as one of the key points of work motivation. That research involves and defines possible aspects which have impact on workplace relationships such as communication, supervisor's personality, managing skills and workplace atmosphere. Research was made in company XY. Main target of the research was to determine how is work motivation of employees influenced by quality of the vertical relationships at the workplace. The respondents were asked about above mentioned aspects to determine which aspects are most important for them. With regard to motivation, majority of respondents mentioned importance of good relationship to their supervisor. Next important point is good atmosphere at the workplace, having impact on employee's work motivation. Personality of supervisor and his attitude to subordinates is also one of main points. Supervisor's qualities should be...
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Synthesis of Isozaleplon Studies
Blahovcová, Michaela ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
SYNTHETIC STUDIES CONNECTED WITH THE PREPARATION OF N-[3-(3-CYANOPYRAZOLO[1,5-a]PYRIMIDIN-5-YL)PHENYL]- N-ETHYLACETAMIDE, A ZALEPLON REGIOISOMER Rigorous Thesis Mgr. Michaela Blahovcová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové This thesis is a continuation of my master thesis and further develops the subject of zaleplon impurities. The main subject of the work is the zaleplon regioisomer, N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide called isozaleplon, which is the most problematic impurity of zaleplon. The purpose of this thesis was to propose a synthetic way leading to isozaleplon based on the available literature. Then this substance was intended to be used as a standard for determination of this impurity in preparation of zaleplon by various methods. The studied approaches to the isozaleplon synthesis were based on Suzuki- Miyaura cross-coupling reaction of the corresponding boronic acids and/or boronates, mainly with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile. Various methods of preparation of both components are described, as well as approaches based on the final modification of the 5-(3-aminophenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile moiety...
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