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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Nasal preparations. Transnasal application.
 Bašová, Martina ; Šklubalová, Zdeňka (advisor) ; Dittrich, Milan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: Doc.PharmDr. Zdeňka Šklubalová Ph.D Student: Martina Bašová Title of Thesis: Nasal preparations. Transnasal application Transnasal application of drugs offers an interesting way of the systemic administration of drugs. Both a high permeability of nasal mucosal tissue and a rich vascularity in a nasal cavity are good preconditions for systemic absorption of nasal drugs. Indeed, there are also the disadvantages associated with the nasal drug application, such as irritative potential of the preparation for nasal mucosa, limit in contact time, and a high activity of the proteolytic enzymes. Peptides represent the large group of nasal substances which are recently very intensively investigated. However, most of peptide drugs is not well absorbed through the nasal mucosa due to their large molecular weight, hydrophilic structure and the low mucosal membrane permeability. This review work deals with factors affecting the transport of peptide drugs through nasal mucosa and the posibilities of modifying of this absorption.
Detailed record
Nasal preparations. Transnasal application.
 Bašová, Martina ; Šklubalová, Zdeňka (advisor) ; Dittrich, Milan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: Doc.PharmDr. Zdeňka Šklubalová Ph.D Student: Martina Bašová Title of Thesis: Nasal preparations. Transnasal application Transnasal application of drugs offers an interesting way of the systemic administration of drugs. Both a high permeability of nasal mucosal tissue and a rich vascularity in a nasal cavity are good preconditions for systemic absorption of nasal drugs. Indeed, there are also the disadvantages associated with the nasal drug application, such as irritative potential of the preparation for nasal mucosa, limit in contact time, and a high activity of the proteolytic enzymes. Peptides represent the large group of nasal substances which are recently very intensively investigated. However, most of peptide drugs is not well absorbed through the nasal mucosa due to their large molecular weight, hydrophilic structure and the low mucosal membrane permeability. This review work deals with factors affecting the transport of peptide drugs through nasal mucosa and the posibilities of modifying of this absorption.
Detailed record

See also: similar author names
1 BAŠOVÁ, Michaela
1 Basová, Miriam
3 Bašová, Magdaléna
1 Bašová, Michala
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