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Chromosomes of parasitic protist Trichomonas vaginalis
 Zubáčová, Zuzana ; Tachezy, Jan (advisor) ; Alsmark, Cecília (referee) ; Vanáčová, Štěpánka (referee)
Charles University in Prague Faculty of Science Programme of study: Parasitology Abstract of Ph.D. thesis Chromosomes of parasitic protist Trichomonas vaginalis Zuzana Zubáčová, MSc. Supervisor: Prof. RNDr. Jan Tachezy, Ph.D. Praha, 2011 Abstract Genome sequencing and associated proteome projects has revolutionized research in the field of molecular parasitology. Progress in sequencing of parasite as well as free-living species enables comparative and phylogenetic studies and provides important data sets for understanding of basic biology and identification of new drug targets. The genome sequencing of Trichomonas vaginalis revealed surprisingly large genome size of this organism (~160 Mb) that resulted from expansion of various repetitive elements, specific gene families and large scale genome duplication. I studied genome sizes of other nine selected species from Trichomonadea group to find whether other trichomonads have undergone similar genome expansion. The measurement of nuclear DNA content by flow cytometry revealed relatively large DNA content in all tested species although within a broad range (86-177 Mb). The largest genomes were observed in the Trichomonas and Tritrichomonas genera while Tetratrichomonas contains the smallest genome. The genome sizes correlated with the cell volume however no...
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