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Development and validation of UHPLC method for determination of meloxicam in dissolution medium
 Švaňová, Petra ; Matysová, Ludmila (advisor) ; Sklenářová, Hana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Petra Švaňová Supervisor: doc. PharmDr. Ludmila Matysová, Ph.D. Title of diploma thesis: Development and validation of a UHPLC method for determination of meloxicam in a dissolution medium This diploma thesis covers the development and subsequent validation of a UHPLC method for determination of meloxicam in a dissolution medium. The columm LiChrospher®, 5 µm RP-18 100 Å (125x4mm) was used for method development. As mobile phase were used methanol, isopropyl alcohol and phosphate buffer (50 mmol/l) in a 51:9:40 ratio, while the aqueous phase pH was adjusted to value 6.8. Flow rate was set to 1.0 ml/min, column temperature was 30řC and injection volume was set to 20 µl. Analytes were detected on the wavelength of 363 nm. The results of the partial validation showed that it is necessary to further optimise the method in order to provide correct results even in the dissolution medium after dissolution.
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