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The influence of the physical activity on high blood pressure in patients with obesity or metabolic syndrome.
Pazderová, Monika ; Matoulek, Martin (advisor) ; Štulc, Tomáš (referee)
Author's first name and surname: Bc. Monika Pazderová Supervisor of the thesis: MUDr. Martin Matoulek, Ph.D. Thesis title: The influence of the physical activity on high blood pressure in patients with obesity or metabolic syndrome Workplace: 3rd Medical Department, 1st Faculty of Medicine, Charles University and General Teaching Hospital in Prague and Health rehabilitation centre VŠTJ MEDICINA Prague Year of thesis defence: 2012 ABSTRACT Nowadays the metabolic syndrome belongs worldwide to the most widespread diseases. The joint occurrence of diabetes, obesity and hypertension has been known for a long time. Also nowadays many doctors consider obesity a typical risk factor for diabetes or hypertension. Generally it is true: the higher BMI the higher likelihood of hypertension occurrence. Hypertension is a risk factor for atherosclerosis which is a cardiovascular disease. Nowadays the high blood pressure belongs to the most common health disorders of populations in both developing and advanced industrialized countries. The complications of hypertension are an important cause of sickness rate, invalidity and death. The occurrence of high blood pressure increases with age and is also dependent on the gender. The average levels of systolic pressure increase with age. On the other hand, the average levels of...
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The importance of the expression of leukocyte and thrombogenic markers in the atherogenesis
Svobodová, Helena ; Štulc, Tomáš (advisor) ; Maruna, Pavel (referee) ; Poledne, Rudolf (referee)
Inflammatory and prothrombotic factors play a crucial role in the atherogenesis. Dyslipidemia and diabetes mellitus as well are associated with the endothelial and leukocyte activation, which facilitate the inflammatory infiltration of the subendothelial space and deteriorate endothelial dysfunction, and thus contribute to the development of premature atherosclerosis. Furthermore, diabetes is associated with a number of platelets and coagulation factors abnormalities that participate in atherogenesis by other mechanisms and may be involved in the acute atherothrombotic events progression. Therefore, the factors that could favourably influence these actions become the subject of interest. In this work, we examined leukocyte expression of cell adhesion molecules in patients with hypercholesterolemia and type 2 diabetes, and thrombogenic molecules on leukocytes in type 2 diabetes, and also soluble endothelial and thrombogenic markers. In these patient groups, we investigated the effect of lipid lowering and antidiabetic treatment on these markers. (...) In contrast, there was nearly no effect of the hypolipidemic and antidiabetic treatment on the serum/plasma endothelial and thrombogenic molecules. Leukocyte molecules may therefore be a more sensitive marker of atherogenesis than circulating endothelial...
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název v anglickém jazyce není uveden
Štulc, Tomáš ; Češka, Richard (advisor) ; Vaverková, Helena (referee) ; Mareš, Jan (referee)
Lipid lowering treatment substantially reduces the risk of cardiovascular diseases. The effects of lipid lowering go far beyond limiting the extent of atheroslcerotic lesions and decreasing the severity of atherosclerotic stenoses. Recently recognised effects of cholesterol on plaque stability, endothelial function, thrombosis, and plaque inflammation have been subject to intensive research during the past two decades. The effect lipid lowering treatment on the various aspects of the plaque development are being investigated in search of novel therapies to reduce the risk of ahterosclerosis. In this work, we examined cell adhesion molecules, microvascular reactivity and metalloproteinase PAPP-A in patients with hypercholesterolemia and investigated the effect of lipid lowering with atorvastatin and LDL-apheresis. Leukocyte and endothelial adhesion molecules mediate leukocyte recruitment into subendothelial space, contributing thus to plaque inflammation. PAPP-A is a protease which has been related to plaque instability and acute coronary events; it's role in stable atherosclerotic lesions hasn't been studied yet Microvascular reactivity is supposed to reflect endothelial function in the microvascular bed; the knowledge of the effect of hyperlipidemia on microvasculature is currently limited. Patients with...
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