National Repository of Grey Literature 6 records found  Search took 0.00 seconds. 
Relationships between Metabolism of Homocysteine and Physiological Formation of Thiodiglycolic Acid
Přistoupilová, K. ; Přistoupil, T. I. ; Šenholdová-Dlasková, Z. ; Navrátil, Tomáš
Thiodiglycolic acid (TDGA), structurally S(CH2COOH)2, is a part of the metabolic pathway used by the human organism to remove dicarbon units produced in catabolic processes TDGA origanates from glycolate and glutathione (GSH). The latter is dependent on the release of cysteine from homocysteine under the influence of vitamins folate and B12.
Thiodiglycolic Acid in Urine
Navrátil, Tomáš ; Šenholdová-Dlasková, Z. ; Heyrovský, Michael ; Přistoupilová, K. ; Přistoupil, T. I.
Thiodiglycolic acid (TDGA) is a physiological intermediate of the metabolism of cysteine which originates from homocysteine transformation. Estimation of increased levels of TDGA in urine reveals indicates intoxication of workers in chemical industry by halogenated organic solvents. Therefore our cheap and simple analytical method of TDGA determination is a contribution to toxicological control in industry.
Determination of Cystine, Cysteine and Homocysteine in Biological Matrix
Bašová, Pavlína ; Navrátil, Tomáš ; Šestáková, Ivana ; Novotný, Ladislav ; Šenholdová-Dlasková, Z.
In order to determine cystine, cysteine and homocysteine contents separately in a mixture of these compounds in real urine samples from patients suffering from cystinuremia and homocistinuremia, three voltammetric methods were tested: Brdička reaction, reduction of their complexes with copper ions and cathodic reduction of cystine. In all cases the hanging mercury drop electrode was used.
Metabolic Causes of Thiodiglycolic Acid Formation and Importance of its Determination
Šenholdová-Dlasková, Z. ; Navrátil, Tomáš ; Přistoupil, T. ; Přistoupilová, K.
Thiodiglycolic acid (TDGA), is one of the normal products of human metabolism, and occurs at low concentrations in urine. An increased level of TDGA in urine is a sensitive indicator of human organism exposure to some physiologically active or toxic substances, gases and vapors (vinylchloride monomer, etc.). The attention was paid to suggestion and explanation of the metabolic pathways related to thiodiglycolic acid in non-exposed organism.

Interested in being notified about new results for this query?
Subscribe to the RSS feed.