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Evaluation of antimicrobial effectiveness of octenidine derivatives
 Šefránková, Laura ; Kovařík, Miroslav (advisor) ; Vávrová, Pavlína (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biological and Medical Sciences Author: Laura Šefránková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Michaela Hympánová, Ph.D. Title: Evaluation of antimicrobial effectiveness of octenidine derivatives Diploma thesis Study program: Pharmacy Introduction: Octenidine dihydrochloride belongs to the group of so-called "gemini" surfactants, or bis-quaternary equivalents of quaternary ammonium salts (QAS). QAS are generally widely used disinfectants exhibiting relatively low toxicity and high efficacy. Bis- quaternary QAS are characterised by even better surface activity and biodegradability. Octenidine dihydrochloride is considered as a very promising antimicrobial agent for its high antimicrobial activity even against multi-drug resistant bacteria. However, its limited solubility in aqueous solvents complicates its application due to the need of organic solvents in product composition, which afterwards reduce wounds or mucous membranes tolerability. Aim: The aim of this work was to test the antimicrobial efficacy of 11 new derivatives of octenidine dihydrochloride, which were prepared with emphasis to increase efficiency and improve solubility in aqueous solutions. Methods: The microdilution broth method...
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