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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Comparison of molecular diagnostic approaches for the detection and differentiation of the intestinal protist Blastocystis sp. in humans
 ŠLOUFOVÁ, Martina
Blastocystis is the most commonly found intestinal protist in the world. Accurate detection and differentiation of Blastocystis including its subtypes (arguably species) is essential for understanding its epidemiology and role in human health. We compared the sensitivity of conventional PCR (cPCR) and qPCR in a set of 288 DNA samples obtained from stool samples of gut-healthy individuals and subtype diversity as detected by next-generation sequencing (NGS) versus Sanger sequencing.
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qPCR diagnostika střevního prvoka \kur{Blastocystis} sp. v souboru vzorků od zdravých lidí
 ŠLOUFOVÁ, Martina
The main aim of this study was to introduce and optimize the qPCR diagnostic protocol for detection of intestinal protist, Blastocystis sp. We compared the sensitivity of conventional PCR (cPCR) and real-time PCR (qPCR) in a set of 288 human samples from gut-healthy individuals and subtype diversity as detected by Next-generation sequencing (NGS) versus Sanger sequencing. The overall prevalence of Blastocystis sp. was 29 %. Based on the results, we found out that qPCR is a more sensitive method than cPCR. In subtype detection, NGS was completely in agreement with Sanger sequencing but showed higher sensitivity for mixed subtype colonization within one host. A combination of these two approaches could be beneficial for future epidemiological studies.
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Mutační status a jiné chromozomální změny u chronické lymfatické leukémie
 ŠLOUFOVÁ, Martina
This thesis is focused on mutation status and other chromosomal changes in chronic lymphocytic leukemia. CLL is a lymphoproliferative illness with a low malignancy based on clonal proliferacy of malignatly transformed B lymphocytes. Although this is the most frequent malignant illness in western population, the cause leading to its origin has not been yet clearly given. Identifying prognostic markers has a significant meaning in identifying the illness prognosis, the choice of treatment strategy, and it influences general survival of patients. The aim of this thesis is to describe the frequency of the most usual mutations in patients suffering from CLL. All the results obtained from CLL patients were acquired from the Hospital in České Budějovice from 2016 to 2018.
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