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Soluble endoglin effects on vascular endothelium
 Ďaďovská, Lucia ; Nachtigal, Petr (advisor) ; Němečková, Ivana (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Soluble endoglin effects on vascular endothelium Diploma thesis Lucia Ďaďovská Supervisor: doc. PharmDr. Petr Nachtigal, Ph.D. Background: We observed the effect of soluble endoglin on expression of VCAM-1 and occurrence of macrophages in descendent aorta in murine models. Analysis was performed by immunohistochemical methods with fluorescence detection. Methods: In this study, we used the transgenic mice overexpressing human soluble endoglin (Sol-Eng+) and control mice with low plasma levels. The both groups were the same age and during the entire three months experiment were fed high fat rodent diet. For results analysis, we used tissue sections of descendent aorta and immunohistochemical methods with fluorescence microscopy detection. Results: Immunohistochemistry showed there was not an evidence of macrophage infiltration in tissue samples of descendent aorta in either control mice or in Sol-Eng+ mice. Immunohistochemical analysis of VCAM-1 expression in descendent aorta of control mice and of Sol-Eng+ mice presented no difference in localization and strength of VCAM-1 expression in both groups. Increased VCAM-1 expression was detected at the exactly same location in both groups -...
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